Surgery for type A intramural hematoma: a systematic review of clinical outcomes
Systematic Review

Surgery for type A intramural hematoma: a systematic review of clinical outcomes

David H. Tian1,2, Adam Chakos1, Lucy Hirst1, Sally T. W. Chung1, Tristan D. Yan1,3

1Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia; 2Department of Anaesthesia and Perioperative Medicine, Westmead Hospital, Sydney, Australia; 3Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia

Correspondence to: David H. Tian. Collaborative Research (CORE) Group, Macquarie University, Balaclava Rd, Macquarie Park, NSW 2109, Australia. Email:

Background: Management of type A intramural hematoma (IMH) remains controversial, with opinions divided as to whether patients should be treated with early aggressive surgery or a more conservative approach. The present systematic review aims to evaluate the mortality and morbidities following surgery for type A IMH.

Methods: Electronic searches were performed on five databases from dates of inception to December 2018. All studies with surgical outcomes for type A intramural hematoma were identified by two independent researchers and relevant data extracted. Random-effects meta-analysis of proportions or meta-analysis of means were performed to aggregate the data. Survival data were pooled using reconstructed individual patient data derived from Kaplan-Meier curves.

Results: Fifteen studies with 744 patients were identified. Ten studies were from Asian countries (73% of patients). Overall mortality was 8.2% [95% confidence interval (CI): 4.6–13.9%]. Mortality from Asian centers was 5.3% (95% CI: 3.6–7.7%) and 18.9% (95% CI: 7.0–40.4%) in Western centers. Postoperative complications were poorly reported and hence not analyzable. Overall pooled survival of 343 patients from four studies at 1-, 2-, 3-, 5-, and 10-year was 91.8%, 90.2%, 89.2%, 87.7%, and 71.1%, respectively.

Conclusions: There is an acceptable level of risk of death after surgery for type A IMH, though significant variations exist between results from Asian and Western centers. More detailed studies are required to clarify the controversies surrounding management of type A IMH.

Keywords: Type A intramural hematoma; systematic review; clinical outcomes

Submitted Aug 15, 2019. Accepted for publication Aug 19, 2019.

doi: 10.21037/acs.2019.08.07


Intramural hematoma (IMH) is a pathological variant of acute aortic syndrome, classically described as a hematoma within the aortic media without communication to the true aortic lumen. However, despite its similarities to aortic dissection, much controversy exists as to the management of IMH, particularly for lesions that involve the ascending aorta (1). Classified as type A IMH, these lesions can have a high propensity to progress to aortic rupture or aortic dissection (2), therefore leading some to advocate for early surgery, similar to acute type A dissections. The present systematic review aims to evaluate the mortality and morbidities following surgery for type A IMH.


Literature search

Electronic searches were performed on Medline, Embase, PubMed, Scopus, and Cochrane Database of Systematic Reviews, from database dates of inception to December 2018. Studies that presented data on surgical outcomes of acute type A IMH management were identified. The search terms (‘intramural hematoma’ or ‘IMH’ or ‘intramural hemorrhage’ or ‘aortic hematoma’) were used either as key terms or MeSH headings. All identified records were evaluated by two independent researchers (DH Tian and A Chakos) according to the inclusion/exclusion criteria. Conflicts were resolved by the senior researcher (DH Tian). Reference lists of the included studies were also reviewed for additional relevant studies.

Inclusion/exclusion criteria

Eligible studies for the present review included any studies that included at least 10 patients who had acute type A intramural hematoma and received surgical treatment within the initial admission. Studies that did not present primary outcomes were excluded. All publications were limited to the English language. Letters, editorials, database registrations, and review articles were excluded.

Outcomes of interest

The primary outcome was mortality (either 30-day or in-hospital). Secondary outcomes included stroke, renal failure, bleeding, and hospital lengths of stay. All data were extracted independently from abstracts, texts, figures, and tables by two independent researchers (L Hirst and STW Chung) into Microsoft Excel. Discrepancies between the two researchers were resolved by the senior researcher (DH Tian). The quality of the studies was assessed using a modified schema used for assessing case series, developed by the Institute of Health Economics (Alberta, Canada) (3) (Table S1). This checklist examines the suitability of study objective(s), design, population, intervention, outcome measure, statistical analysis, appropriateness of results and conclusions, and competing interests.

Statistical analysis

Table S1
Table S1 Modified quality assessment checklist, adapted from Quality Appraisal Tool for Case Series Studies published by Institute of Health Economics (Alberta, Canada)
Full table

Descriptive statistics were calculated for all collected variables. Categorical or continuous variables were aggregated using random-effects meta-analysis of proportions or means, as appropriate. Data are presented as N (%) with 95% confidence intervals or mean ± standard deviation (SD). Data that were presented as median and interquartile ranges were converted into mean ± SD using the methods of Wan and colleagues (4). Survival curves were aggregated using the method of Guyot and colleagues, which reconstructs individual patient data from digitized Kaplan-Meier curves using an iterative algorithm (5). All statistical analyses were performed in R (version 3.5.2, R Foundation for Statistical Computing, Vienna, Austria).


Literature search

Overall, 5,133 unique records were identified from the literature search (Table 1). Following review, 15 were included in the quantitative analysis (6-20), with a total of 744 patients. Four were multi-center studies (7,15,17,20), including an international registry (7). The median size of the included studies was 25 patients (interquartile range 16–53). All were retrospective analyses of prospectively or retrospectively collected data. Ten of fifteen studies, including 73% of patients, were from Asian centers.

Table 1
Table 1 Study characteristics and clinical outcomes
Full table

The quality of the studies was varied. Two studies were deemed high-quality, nine as medium-quality, and four as low-quality studies. Nearly half of all studies did not identify whether patient recruitment was consecutive. Adverse events were reported by less than half of all studies.

Overall mortality was 8.2% [95% confidence interval (CI): 4.6–13.9%; I2=69%]. Meta-regression with region of study (Western vs. Eastern countries) found that this alone accounted for 62% of the identified heterogeneity (P<0.001). Indeed, further subgroup analysis found pooled mortality of 18.9% in Western studies (95% CI: 7.4–40.4%, I2=77%), compared to 5.3% in Eastern studies (95% CI: 3.6–7.7%, I2=0%).

Permanent neurological deficit was only reported in five studies, with an incidence of 7.6% (95% CI: 4.2–13.2%; I2=52%). Remaining outcomes were poorly reported and were not able to be aggregated.

Four studies presented survival data for 342 patients undergoing urgent surgery (9,10,12,16). Pooled overall survival at 1-, 2-, 3-, 5-, and 10-year was 91.8%, 90.2%, 89.2%, 87.7%, and 71.1%, respectively (Figure 1).

Figure 1 Overall survival after surgery for type A intramural hematoma. Data aggregated from four studies using methods of Guyot and colleagues (5).


The management of type A intramural hematoma remains controversial. Some studies recommend early surgery for these patients due to poor prognosis with medical management (21), while others have demonstrated acceptable outcomes with medical therapy alone and timely operation (10). Indeed, progression to aortic rupture or aortic dissection occurs in up to 45% of patients with ascending aortic IMH (20), with the proximal location of IMH considered an independent predictor of complications in numerous studies (2,7,22). In the present analysis, surgical mortality for type A IMH was 8.2%, arguably lower than the risks of medical management (20,21).

The evidence for management of IMH remains conflicted, with disparate findings across regions. While most Western institutions advocate urgent surgery for type A IMH, some Asian centers have shown acceptable outcomes with medical management and delayed surgery (10,16). While Western guidelines recognize IMH to be a subset of acute aortic syndrome, some Asian societies consider IMH to be a distinct pathological process that requires unique consideration of treatment (23). Indeed, the 2010 American College of Cardiology Foundation and the American Heart Association (ACCF/AHA) guideline and 2014 European Society of Cardiology guideline both recommend urgent surgery (24,25) (Class IC recommendation), whereas the 2011 Japanese Circulation Society recommends medical therapy (Class IC recommendation) for type A IMH (26). In the present study, the mortality for Western institutions was 18.9%, compared to 5.3% for Eastern centers, although significant heterogeneity between the Western studies existed. Two Western studies contributed the majority of surgical mortality; a Spanish single-institutional series reported seven deaths from 16 operations (four intraoperative deaths, two deaths from hypoxic encephalopathy, and one from stroke) (8), while six deaths were reported from 14 operations in the IRAD series (7). The lack of information and heterogeneity regarding patient comorbidities, presentation and patient selection, surgical approach, and extent of surgery precludes recommendations based on these results.

The timing of surgical intervention for type A IMH is of significant interest to clinicians. In a study of 101 patients with type A IMH by Sandhu and associates in Houston, USA, the median time to surgery was 55 hours, with only a small proportion of patients undergoing emergent surgery (16). This is in concordance with other reports suggesting that deferring non-emergent surgeries may be advantageous, particularly as it may allow time for the aortic wall to thicken and the intimal flap to stabilize (6,10,16,27). However, the risk of rupture during index admission is not insignificant, reported as up to 18% in some studies (2). As such, there remains a lack of consensus regarding the timing of surgery, which requires further multi-institutional data to clarify.

There are limitations to the present study that must be considered when interpreting the results. Firstly, the patient cohort includes those who are under surveillance and have survived to the operating theatre, rather than all operative and non-operative type A IMH patients. Secondly, type A IMH is a relatively rare condition, and therefore this summary is based mostly on aggregation of small case series. The heterogeneity introduced by this reporting bias cannot be adequately controlled, particularly in the absence of larger multi-institutional studies. Thirdly, this review includes all surgical patients, including those who underwent initial emergency operation and those who had staged procedures. Conclusions regarding which approach is superior is beyond the scope of the present data. Finally, patient comorbidities and surgical approach cannot be standardized between studies due to the lack of presented information.

The present systematic review of surgical outcomes of type A IMH identified an acceptable risk of postoperative mortality. However, significant heterogeneity exists in outcomes for Western and Eastern centers. The lack of detailed data precludes further robust analysis of key clinical questions.




Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: Tian DH, Chakos A, Hirst L, Chung ST, Yan TD. Surgery for type A intramural hematoma: a systematic review of clinical outcomes. Ann Cardiothorac Surg 2019;8(5):518-523. doi: 10.21037/acs.2019.08.07

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