Management of retrograde type A IMH with acute arch tear/type B dissection
Keynote Lecture Series

Management of retrograde type A IMH with acute arch tear/type B dissection

Foeke Nauta1, Hector de Beaufort2, Firas F. Mussa3, Carlo De Vincentiis4, Atsushi Omura5, Hitoshi Matsuda5, Santi Trimarchi6,7

1Department of Cardiothoracic Surgery, Amsterdam UMC, Amsterdam, The Netherlands; 2Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands; 3University of South Carolina School of Medicine, Columbia, SC, USA; 4Department of Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy; 5Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan; 6Department of Surgery, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan, Milan, Italy; 7Department of Clinical and Community Sciences, University of Milan, Milan, Italy

Correspondence to: Santi Trimarchi, MD, PhD. Department of Surgery, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan, Italy; Department of Clinical and Community Sciences, University of Milan, Milan, Italy. Email: santi.trimarchi@.unimi.it.

The incidence of intramural hematomas (IMH) in acute dissection (AD) patients varies between 6% and 30% in the literature, most frequently involving only the descending aorta (58%) than the arch or ascending aorta (42%). In this setting, IMH that initiate in the descending aorta, but extend into the arch or ascending aorta have been described, and referred to as a retrograde type A IMH. In these patients the risk of neurological or cardiac complications are high, and therefore an open surgical or hybrid approach has been proposed as the most appropriate. Nevertheless, the endovascular management of such lesions in surgically unfit patients for open surgery have been offered with acceptable outcomes, although the risk of landing in an unsuitable proximal landing zone is evident. In conclusion, retro-TAIMH is an acute aortic syndrome and should be managed as such. The recommended treatment strategy is open surgery for treating ascending or arch involvement, and TEVAR/medical, based on a complication-specific approach, for those with only descending localization. In those patients in whom retro-TAIMH is associated with an acute B dissection presenting with a proximal entry tear located into the descending aorta, a TEVAR represents an option treatment.

Keywords: Dissection; intramural hematoma; aorta


Submitted Jul 01, 2019. Accepted for publication Aug 04, 2019.

doi: 10.21037/acs.2019.08.05


Video Management of retrograde type A IMH with acute arch tear/type B dissection.

Definitions and incidence of aortic intramural hematoma

An acute aortic intramural hematoma (IMH) is defined by the presence of hemorrhage within the aortic wall without evidence of an intimal tear. This aortic injury may evolve into an aortic dissection (AD) and/or rupture and is then often lethal. It is therefore considered an acute aortic syndrome. The Stanford classifications of AD are also used for IMH, with type A IMH (TAIMH) defined as involvement of the ascending aorta, and type B IMH (TBIMH) defined as lack of involvement of the ascending aorta. Intramural hematomas that initiate in the descending aorta, but extend into the arch or ascending aorta are referred to as a retrograde type A IMH (retro-TAIMH, Figure 1). The incidence of IMH in AD patients varies between 10% and 30% in the literature (1-5). In the largest series based on the International Registry of Acute Aortic Dissection (IRAD), the overall incidence of IMH among all acute dissections was 6% (6). Most IMH patients present with hematoma involving only the descending aorta (58%), rather than the arch or ascending aorta (42%). This is contrary to classic AD, which is primarily regarded as type A AD.

Figure 1 Retro-TAIMH that originates in the descending aorta with retrograde extension into the arch, on a sagittal view (A) and axial view (B). TAIMH, type A intramural hematoma.

Etiology and clinical presentation

The etiology of IMH has not been completely elucidated. It has been suggested that IMH originates from ruptured vasa vasorum in weak areas of the medial layer of the aortic wall, triggering a tear into the aortic lumen (7,8). Another proposed concept is that IMH originates from small intimal tears followed by thrombosis of these tears, making the tears difficult to detect on imaging studies (8,9). Both concepts are likely to be induced by increased wall stresses on already weakened tissue. Several potential clinical risk factors have been identified for IMH, such as higher age, large aortic diameter and increased aortic wall thickness (6,10,11).

The clinical presentation of IMH patients is quite comparable to those suffering from AD. The vast majority present with acute chest pain and may show hemodynamic instability (7). However, the Houston group showed that age over 65 years, female gender, Marfan syndrome and retrograde dissection are all significantly correlated to TAIMH when compared to type A aortic dissection (TAAD) (12). Moreover, IMH patients show fewer distal malperfusion syndromes, such as mesenteric or limb ischemia, than AD patients, as there is no intimal flap disrupting aortic flow (6,11,12). In addition, cardiac tamponade is more frequently found in TAAD than in TAIMH as result of AD rupture into the pericardium (6,13).


Diagnostic imaging

Modern imaging has led to a better understanding of aortic injuries. It has been shown that IMH is relatively common in patients with suspected AD (10% to 30%) (14-18). High quality CT and MRI imaging show that IMH and AD may be present at the same time in different levels of the aorta (Figure 2). Aortic dissection presenting with a thrombosed false lumen can resemble an IMH as entry tears are often no longer visible. In order to differentiate between these conditions, cross-sectional imaging is considered the gold standard. Importantly, the close relationship between an IMH and the adventitia may lead to aortic rupture (19). It is therefore vital to distinguish pleural effusion, usually a benign sign, from a peri-aortic hematoma, frequently a sign of (impending) aortic rupture. The presence of peri-aortic hematoma is suggestive of IMH rather than AD, as it is comparatively more commonly associated with IMH. Furthermore, high quality imaging can expose small intimal lesions in the inner curvature of the aortic arch, which are more common in IMH than in AD. Such signs may support the process of making a diagnosis, as well as the planning of thoracic endovascular aortic repair (TEVAR) (20). Further radiological differences between IMH and AD involve aortic wall thickening and the shape of hematomas. For IMH, axial imaging reveals thickening of the aortic wall greater than 0.5 cm in an eccentric or concentric pattern, with a linear intraluminal filling defect as a distinguished feature (Figure 3). On the contrary, thrombosed false lumen in acute AD shows curvilinear intramural clots, often missing a well-defined outer wall because of mediastinal hematoma and pleural effusions (14). As for aortic diameters, no clear differences were found between patients with IMH or AD, with an average of 5 cm for the ascending aorta and 4 cm in the descending aorta (6,21).

Figure 2 Retro-IMH that originates in the descending aorta (A) with retrograde extension into the ascending (B). IMH, intramural hematoma.
Figure 3 Axial view of ascending aortic wall thickening suggesting IMH (A). Sagittal view of IMH in the descending aorta with aortic wall thickening and linear intraluminal filling defect (B). IMH, intramural hematoma.

Prognosis

The prognosis of acute IMH is comparable to that of acute AD. While it was formerly thought that IMH would be less dangerous, several clinical studies have underlined that early and long-term mortality of IMH do not differ from AD (6,11,13). In-hospital mortality varies between 12–26% for type A IMH and AD, and from 5% to 11% for TBIMH and AD (6,11,21). Similar to TAAD, IMH involving the ascending aorta is a lethal condition and is an indication for expeditious surgery because of the risk of cardiac tamponade, rupture or compression of the coronary ostia (6,8,10,11). In particular, IMH concomitant with PAU is associated with an increased risk of expansion and rupture (14,22) (Figure 4). For IMH alone, even though 34% of patients will show regression, 16% to 47% of patients will progress to development of AD (8,10,22,23) and 20% to 45% will develop an aortic rupture (8). The best predictor of IMH regression without complications is a normal aortic diameter in the acute phase (19). With regards to adverse aortic remodelling, Evangelista et al. reported that amongst 68 IMH patients, 22% developed a fusiform aneurysm, 8% a saccular aneurysm and 24% a pseudoaneurysm (over a mean time of 45 months) (23). It is therefore important to monitor all IMH patients closely.

Figure 4 IMH concomitant with a penetrating aortic ulcer. IMH, intramural hematoma.

Medical

Optimal management of TAIMH remains debatable. Most Western sites opt for emergent surgical aortic repair for unstable patients. Nonetheless, several Asian sites have reported promising results with initial medical treatment in TAIMH patients (2,24). It is important to note that such centres report markedly higher incidences of TAIMH in acute aortic syndrome patients than Western sites. It is still unclear if this is caused by different definitions or by a truly different etiology. Currently, in most IRAD centres, patients who present with TAIMH but are clinically stable at presentation are typically first managed medically, in anticipation of sub-acute surgical repair (7,12).

In general, IMH located in the aortic arch or descending aorta are less likely to be associated with adverse outcomes than TAIMH, and therefore best medical therapy may suffice (10). Primary management of patients presenting with uncomplicated IMH consists of medical therapy and intensive monitoring (6,11,18). Medical management includes urgent blood pressure normalization and left ventricular ejection fraction reduction, as they are the main determinants of dissection extension and rupture. β-blockers have been shown to decrease mortality by 67% to 95% (22) and should be given at highest tolerated doses. Calcium channel blockers are considered the alternative medication of choice. To normalize hypertension caused by stimulation of adrenergic receptors, adequate analgesic therapy should be initiated, preferably with morphine sulphate (10,11,14,18,22,25). For TBIMH patients, refractory chest pain, evidence of increasing size of the hematoma, aortic rupture and progressive pleural effusion are indications for endovascular or surgical treatment (22).

Thoracic endovascular repair

Endovascular repair is indicated in symptomatic/complicated TBIMH patients due to the risk of rupture (14,25,26) (Figure 5) and is associated with lower perioperative morbidity and mortality than open repair (20,27-29). The focal character of the aortic lesion makes TBIMH patients suitable candidates for endovascular treatment (11,30). Although the literature provides no convincing guidelines for IMH treatment, it seems reasonable that it is similar to treatment of type B AD in corresponding segments of the aorta (31,32). Currently, TEVAR may be indicated in patients with progression of IMH towards overt dissection or rupture (20,31). However, an important risk of TEVAR in extended IMH is that the endograft may tear through the intimal surface into underlying thrombosed false lumen. Thus, the endograft should be anchored in the noninvolved wall above and below the intimal defect (32). A recent study by Kuo et al. showed that the presence of IMH at the proximal landing of TEVAR seemed to increase the risk of retrograde TAAD (6.7% vs. 0%) (33). Although this finding was not statistically significantly, it suggests that a 2-cm IMH-free landing zone should be obtained, even if this means that an arch debranching is necessary. In patients presenting with retro-AIMH, the risk of neurological or cardiac complications is high, and therefore an open surgical or hybrid approach is most appropriate (11,34) (Figure 6). The risk of landing in an unsuitable proximal landing zone (i.e., development of a retrograde dissection), which is the main concern of endovascular repair in retro-IMH, might be of less relevance in retrograde TAAD, since the retrograde dissection is already there. In a still unpublished work, Omura et al. describe the use of TEVAR in landing zones 1 to 4 for a small subgroup of patients with retrograde TAAD and an entry tear in the descending aorta (35). These 8 patients were considered to be at prohibitive surgical risk, but the achieved outcome was very good: 30-day mortality was 0% and, interestingly, postoperative CT scans showed complete thrombosis and reduction in size of the false lumen in the ascending aorta in all patients (Figure 7). In addition, some small case series on retro-TAIMH have recently reported acceptable outcomes with endovascular repair (36,37).

Figure 5 IMH with crescentic thickness evolving over time, with recurrent pain at day 10 (A). TEVAR in Z2 with left carotid-subclavian bypass and plug at the LSA origin, and the axial view (B). IMH, intramural hematoma; TEVAR, thoracic endovascular aortic repair.
Figure 6 Ascending aortic intramural hematoma.
Figure 7 Aortic remodeling following thoracic endovascular repair for retrograde type A aortic dissection.

Surgical

Surgical aortic repair remains the gold standard for patients presenting with complicated TAIMH (hemodynamic instability, persistent pain, or signs of rupture) (7,31,32). The surgical technique in TAIMH consists of ascending aortic repair to prevent aortic rupture and proximal extension of the IMH. Although the aortic wall adjacent to the IMH might not be visibly pathological, the use of felt to reinforce the anastomoses is indispensable, and bio-glue is often added as well. The distal extent of repair is determined by the diameter of the aortic arch. Enlargement of the arch >5 cm is not uncommon, especially in cases of type B dissection with retro-TAIMH, and concomitant arch repair may be required (12). Some centers even use a threshold of 4 cm (38). If this is not the case, a partial arch replacement with open distal anastomosis may suffice. Use of deep hypothermic circulatory arrest with selective cerebral perfusion, in combination with intraoperative cerebral monitoring with transcranial Doppler and/or EEG, is generally required.

The proximal extent of the repair is determined by involvement of the aortic root and aortic valve. As these are less commonly involved in TAIMH than in TAAD, aortic root replacement or aortic valve resuspension are not as often required in TAIMH (15%) as in TAAD (36%) (6). Therefore, surgical procedure times for TAIMH are significantly shorter than for TAAD. However, outcomes did not differ for stroke (13% and 7% respectively) and mortality (12–26% and 16–26% respectively (6,12). In the IRAD group, 24 patients had the most proximal extension of IMH in the arch. Of these, 16 were medically managed, 4 were surgically managed, 2 were managed with endovascular therapy, and 2 by a hybrid approach (6,39).

A hybrid approach can be considered, especially in retro-TAIMH patients. There are two main options for hybrid repair. The first is (supracoronary) ascending and partial arch replacement with debranching of the brachiocephalic and left common carotid artery, creating a safe landing zone for subsequent TEVAR, which is done to complete the procedure. This option allows relatively good exposure and controlled creation of the distal anastomosis, and might be preferable in the acute setting. A downside is the deliberate overstenting of the left subclavian artery, as it is often unknown whether a patient has a complete circle of Willis. The second option is ascending and total arch replacement with a frozen elephant trunk (Figure 8) with additional TEVAR if necessary, in a single stage procedure. As experience with hybrid techniques is increasing, such extensive repairs are gaining popularity for the acute setting, since they are thought to offer more favorable results on aortic remodeling of the thoracoabdominal aorta. However, there are currently no reports describing the surgical results specifically for retro-TAIMH. For TAAD, a pooled analysis of published results of hybrid techniques showed a 30-day mortality of 5–12% (40). It should be noted that these results are based on retrospective analyses, so there is a potential publication bias.

Figure 8 CT-imaging of a patient with retro-TAIMH in the arch. The red arrow shows the thicker section of the retro IMH located at the origin of the left common carotid artery. The patient was managed with ascending-arch repair and frozen elephant trunk. TAIMH, type A intramural hematoma.

Optimal management of uncomplicated TAIMH is a matter of debate. Some authors state that these patients may be managed medically, and have reported promising results (4,41). However, about 25% of these patients still need urgent surgical repair (41). In another series, 43% of patients who were initially managed medically needed surgical repair within 1 year of presentation (42). In the IRAD group, of 10 patients with TAIMH managed medically, 4 patients died in-hospital (3 because of rupture and 1 due to aortic dissection with mesenteric ischemia). Therefore, patients with TAIMH who are managed medically should be monitored closely (4,41).

Follow up

A five-year follow-up for both IMH type A and type B is advised (43). IRAD investigators believe life-long medical therapy for strict blood pressure regulation is indicated for all patients (11,44). In addition, it has been reported that aortic enlargement for TBIMH during follow-up was significantly less common compared to type B AD patients (39% vs. 61%; P=0.034) (11).


Conclusions

Retro-TAIMH is an acute aortic syndrome and should be managed as such. The recommended treatment strategy is open surgery for treating ascending or arch involvement, and TEVAR/medical, based on a complication-specific approach, for those with only descending localization. For patients in whom retro-TAIMH is associated with an acute type B dissection presenting with a proximal entry tear located into the descending aorta, TEVAR is an option for treatment.


Acknowledgments

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: Nauta F, de Beaufort H, Mussa FF, De Vincentiis C, Omura A, Matsuda H, Trimarchi S. Management of retrograde type A IMH with acute arch tear/type B dissection. Ann Cardiothorac Surg 2019;8(5):531-539. doi: 10.21037/acs.2019.08.05

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