The choice of mitral annuloplastic ring—beyond “surgeon’s preference”
Research Highlight

The choice of mitral annuloplastic ring—beyond “surgeon’s preference”

Song Wan1, Alex P. W. Lee2, Chun-Na Jin2, Randolph H. L. Wong1, Herman H. M. Chan1, Calvin S. H. Ng1, Innes Y. P. Wan1, Malcolm J. Underwood1

1Division of Cardiothoracic Surgery, Department of Surgery, 2Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China

Correspondence to: Song Wan, MD, FRCS. Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. Email:

Submitted Oct 05, 2014. Accepted for publication Dec 15, 2014.

doi: 10.3978/j.issn.2225-319X.2015.01.05


Annuloplasty is a fundamental component in mitral valve repair. According to Carpentier’s original concepts, an annuloplastic ring is essential for the following three reasons: (I) to restore the size and shape of the native annulus; (II) to prevent future annular dilatation; and (III) to provide functional annular support. Logically, Carpentier designed his annuloplastic ring to remodel the annulus into the shape it takes in the systolic phase (1). Because the entire mitral valvular structure experiences the highest stress during this phase, this particular configuration may restore maximal leaflet coaptation (1). Over the past two decades, although the choice of annuloplastic ring has been the focus of extensive investigation and debate, to date it still largely remains a matter of “surgeon’s preference” rather than an evidence-based selection. In fact, only a handful of prospective randomized clinical trials had ever been conducted and existing knowledge on this particular subject is far from conclusive (2).

The impact of an annuloplastic ring

To properly address the issue of ring choice, in-depth understanding of the related pathophysiology is crucial. Miller’s group at Stanford University (3-6) and Gorman’s group at University of Pennsylvania (7-9) have made substantial contributions to understanding of the mechanisms involved in mitral annuloplasty. These researchers’ observations of the 3-dimensional (3D) dynamics of the mitral valve showed that without ring implantation, the mitral annular area varied throughout the cardiac cycle. Regardless of the type of ring implanted, the mitral annular area and shape were almost fixed after ring annuloplasty (3,4). In particular, ring annuloplasty markedly reduced the mobility of the central posterior leaflet, so that valve closure was largely a single anterior leaflet process with a frozen posterior buttress (4,5). Moreover, the minimum mitral area observed during the cardiac cycle without a ring was nearly 50% larger than the “fixed” annular area with a semi-rigid or flexible ring (4,5). Hence, regardless of ring choice, mitral annuloplasty may unavoidably reduce the mitral annular area and prohibit the motion of the posterior leaflet. Based on such considerations, some surgeons elected to avoid implanting a ring whenever possible (10-14).

Few randomized studies so far have provided convincing long-term data comparing the durability of annuloplasty with and without prosthetic rings. However, several large series from centers of excellence have demonstrated the efficacy of the ring in preventing the late recurrence of mitral regurgitation. DiBardino et al. (15) and Gillinov et al. (16,17) confirmed a significant advantage of ring annuloplasty over no-ring repair in terms of the durability of reconstruction. In a recent Cleveland Clinic report involving 3,074 patients with isolated posterior leaflet prolapse, the lack of a prosthetic ring annuloplasty was an independent risk factor for the postoperative return of mitral regurgitation (18). On a separate note, these observations indeed underline the potential disadvantage in some recently developed percutaneous mitral valve “repair” techniques where the intervention is focused only on the leaflets.

The Cleveland Clinic series (18) predominantly used the Cosgrove flexible band, which was primarily designed for preserving mitral annular dynamics (19). It has been suggested that the saddle shape and the sphincter mechanism of the mitral valve can be preserved for up to five years after implantation of this band (20). The Mayo Clinic group also reported good mid-term outcomes for the routine application of a flexible but “standard-sized” (unmeasured) posterior annuloplasty band (21). However, there is still a lack of real long-term data on the durability of the flexible band.

The routine use of a flexible partial band may carry some potential drawbacks. It appears logical to suspect that due to pannus formation with subsequent fibrotic changes and calcifications (22), the band may become more rigid over time. Thus, it remains doubtful as to whether the annular saddle shape and sphincter mechanism can be maintained beyond the mid-term. Additionally, few would argue that the flexible band is unlikely to retain a saddle shape if the native annulus was flattened in the first place. Most importantly, the C-shaped flexible band is inherently unable to restore the 3:4 (vertical:transverse) annular physiological relationship originally proposed by Carpentier et al. (1).

The importance of saddle-shaped annuloplasty

Although the mitral annular saddle shape (Figure 1) has long been recognized and carefully studied, its clinical relevance was not fully appreciated until recently. Using real-time 3D transesophageal echocardiography (TEE), we (23) observed that the annular saddle shape was closely related to the scale of leaflet prolapse, the extent of chordal elongation, and the frequency of chordal rupture, and consequentially that it determined the evolution of mitral regurgitation in patients with mitral valve prolapse. This in vivo human evidence highlighted the significance of the annular saddle shape in disease progression. Recently, we (24) also found that obvious mitral annular disjunction (defined as a separation between the atrial-mitral valve junction and ventricular attachment) was evident in 20 out of 96 (21%) patients with myxomatous mitral valve prolapse. Compared with the remaining 76 patients, the patients with mitral annular disjunction had significantly greater commissural width, shorter annular height, but similar annular anteroposterior diameter, area and circumference, resulting in a flatter and more elliptical annular shape. Annular unsaddling, defined as annular height to commissural width ratio (AHCWR) less than 15%, was significantly more prevalent in the group with mitral annular disjunction than without (90% vs. 46%, χ2=9.674, P=0.002). Mitral annular disjunction was also associated with significantly greater leaflet billowing volume and longer chordal lengths. Our findings suggested that mitral annular disjunction may contribute to the change of mitral valvular 3D geometry, with reduced annular height and loss of the saddle shape.

Figure 1 Three-dimensional illustration of mitral valve geometry in a normal subject with a saddle-shaped annulus. AL, anterolateral; PM, posteromedial; A, anterior; P, posterior; Ao, aortic annulus.

Importantly, serial investigations by the Gorman group have discovered that the saddle-shaped annulus reduces strain on the mitral leaflet, particularly at the P2 site (25-27). On the one hand, accumulating clinical evidence indicates that such a saddle shape is distorted in patients with myxomatous or ischemic mitral regurgitation (9,23,24). On the other hand, Jensen and colleagues (28-30) showed that a saddle-shaped annuloplasty ring can provide a more favorable and uniform annular force distribution when compared to the flat ring. The saddle ring can maintain the medial alignment of the papillary muscles to facilitate proper leaflet coaptation (29,30). Therefore, by diminishing mitral leaflet strain and improving leaflet coaptation geometry, saddle-shaped annuloplasty may enhance repair durability. Again, to maintain the annular saddle shape, it is sensible to choose a complete annuloplastic ring rather than a flexible C-shaped band.

“Saddle ring for all patients” versus a tailored selection

We, like many other groups, had adopted different annuloplasty strategies over the past decades, ranging from “no ring whenever possible” at the early phase of our valve repair program, to the current practice of using a complete saddle-shaped ring almost exclusively. In the past ten months, however, we have observed that the native mitral annular saddle shape could often be well preserved in patients suffering from a relatively short duration of mitral regurgitation. Such a phenomenon is particularly true in those young patients with acute infective endocarditis. Based on our own experience, a semi-rigid ring rather than a saddle-shaped ring can provide more reliable repair results in this particular patient subgroup. Indeed, Carpentier’s statement remains inspiring even 30 years later: “one may define the aim of a valve reconstruction as restoring normal valve function rather than normal valve anatomy” (31). For a durable mitral valve repair, it remains controversial whether a saddle-shaped annuloplasty should be applied to every patient. In fact, it was proposed that mitral annular dynamic changes (i.e., “flexibility”) may largely be limited following a saddle-shaped annuloplasty using either a Physio-II ring or a Rigid Saddle ring (32).

For the purpose of tailored selection of an annuloplastic ring, we (33) prospectively performed 3D-TEE in 31 normal subjects (the control group) and in 88 patients with degenerative mitral regurgitation prior to surgical mitral valve repair. Zoomed real-time 3D-TEE images of the entire mitral complex, including annulus, leaflets, papillary muscles and the aortic valve, were acquired. Quantitative morphological analysis of the mitral valve was performed with custom software (QLAB MVQ, Philips Healthcare, Andover, MA, USA). The reconstructed valve was displayed as a color-coded 3D-rendered surface representing a topographical map. Measurements of the key 3D geometric parameters of the mitral annulus were automatically generated. AHCWR was calculated as a surrogate of the annular saddle-shape. Group comparisons used one-way ANOVA or the χ2 test as appropriate. Post hoc comparisons used LSD tests.

Main echocardiography findings

We observed that AHCWR ranged from 15-33% (mean ± SD =24%±5%) in the normal control group. Annular flattening, defined as AHCWR <15%, was evident in 71% of patients with anterior leaflet or bi-leaflet prolapse and in 53% of those with isolated posterior leaflet prolapse. Moreover, height and AHCWR were both significantly lower in the anterior- or bi-leaflet prolapse group than in the isolated posterior leaflet prolapse group, despite the annular area, circumference, commissural width and anteroposterior diameters all being similar between the two groups. Thus, we confirmed that annular flattening is common in patients with mitral valve prolapse, but the degree of such flattening appears to be more marked in those with anterior leaflet or bi-leaflet prolapse. In these patients, a saddle-shaped annuloplasty may be more important in restoring annular geometry and function.

Clinical results

Over the same four-year study period, 198 consecutive patients underwent mitral valve repair at our institution. Among them, 189 received saddle-shaped annuloplasty (including nine emergency cases with preoperative IABP and/or mechanical ventilatory support). Concomitant aortic valve replacement (n=17), tricuspid repair (n=91) or coronary artery bypass grafting (n=42) were carried out. The overall 30-day surgical mortality was 2.5% (n=5).

Ring selection (AHCWR <15%)

We selected the Physio-II ring (Edwards Lifesciences, Irvine, CA, USA) for patients with degenerative mitral regurgitation when true-size annuloplasty is indicated (n=131). Meanwhile, we chose the Rigid Saddle ring (St. Jude Medical, St. Paul, MN, USA) for patients with functional or ischemic mitral regurgitation (n=58) that warrants a down-sizing annuloplasty (Figure 2). Over a mean follow-up of 2.8 years, the majority of patients (97%) had less than mild to moderate (2+) mitral regurgitation. The recurrence of moderate to severe mitral regurgitation was found in only two patients in the Physio-II group and three patients in the Rigid Saddle ring group.

Figure 2 Intra-operative pictures showing the final results of the saddle-shaped mitral valve annuloplasty.

Ring selection (AHCWR ≥15%)

We found that a semi-rigid ring rather than a saddle-shaped ring may provide more reliable repair results in patients whose AHCWR remained within the normal range. We have chosen the Memo 3D ring (Sorin SpA, Milan, Italy) under such circumstances with satisfactory early results (n=9). Postoperative 3D-TEE confirmed that mitral annular saddle shape is well preserved in these patients (AHCWR ranged from 15-18%).


Taken together, the use of a saddle-shaped ring rather than a flat ring may enhance the mechanical benefits conferred by mitral annuloplasty. Aiming to preserving native mitral annular saddle shape or performing a saddle-shaped annuloplasty, we routinely use 3D TEE to measure the AHCWR prior to every mitral valve repair operation for an individualized selection of the appropriate annuloplastic ring. Indeed, the benefit of such a clinical implication is yet to be evaluated prospectively in a large patient population with adequate long-term follow-up.


Disclosure: The authors declare no conflict of interest.


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Cite this article as: Wan S, Lee AP, Jin CN, Wong RH, Chan HH, Ng CS, Wan IY, Underwood MJ. The choice of mitral annuloplastic ring—beyond “surgeon’s preference”. Ann Cardiothorac Surg 2015;4(3):261-265. doi: 10.3978/j.issn.2225-319X.2015.01.05

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