Thoracoscopic thymectomy in a patient with pemphigus
Masters of Cardiothoracic Surgery

Thoracoscopic thymectomy in a patient with pemphigus

Ashleigh Xie1, Tristan D. Yan1,2

1The Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia; 2Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia

Correspondence to: Tristan D. Yan, MD, MS, PhD, FRACS. Professor of Cardiovascular and Thoracic Surgery, Macquarie University Hospital, Sydney, Australia; The Collaborative Research (CORE) Group, Macquarie University, 2 Technology Place, Sydney, Australia. Email:

Submitted Nov 12, 2015. Accepted for publication Nov 18, 2015.

doi: 10.3978/j.issn.2225-319X.2015.11.03

Video Thoracoscopic thymectomy in a patient with pemphigus.

Clinical vignette

The presenting case is a 50-year-old man with pemphigus foliaceus who was found to have a thymoma. Computed tomography (CT) scans revealed a large anterior mediastinal mass, 6 cm in diameter, which was heterogeneous in appearance with no evidence of invasion. CT-guided biopsy confirmed the diagnosis of type AB thymoma. The patient was otherwise functionally independent, with an Eastern Cooperative Oncology Group (ECOG) status of 1 and normal pulmonary function. Informed consent was obtained for a video-assisted thoracoscopic surgery (VATS) radical thymectomy.

Surgical techniques

Preparation and exposition

The patient was positioned supine, with the right side of the chest supported by a pillow. A 5-cm minithoracotomy incision was made in the 4th intercostal space below the right nipple. A soft tissue retractor was then inserted. A 1-cm utility port was inserted through the 4th intercostal space, posterior to the minithoracotomy incision, along the anterior axillary line. A 5-mm camera port was then inserted to accommodate the thoracoscope in the 5th intercostal space along the anterior axillary line. The thoracoscope remained in this port for the remainder of the procedure, and an additional 1 cm access incision was created in the 4th intercostal space in the posterior axillary line.


The camera provided excellent visualization of the entire anterior mediastinum. There was no evidence of pleural metastasis on inspection. A peanut mounted on a Roberts forceps was used to lift the edge of the thymic tumor off the pericardium. Unipolar ball-tip diathermy was used to carefully dissect the thymoma from the pericardium, by placing the tip of instrument at the interface of the tumor and normal tissues and applying focal traction to each point of dissection. A power setting of 60-80 watts was used.

The surgical margins included the mediastinal pleura medially, the right phrenic nerve laterally, the innominate vein and thymic horns superiorly, and thymic fat pad inferiorly. The left pleural space was opened to facilitate en bloc dissection of the thymoma. The thymic veins were visualised superiorly, and ligated flush against the innominate vein.

In this particular case, the thymic mass was encapsulated, without any breach of the capsule during the procedure (Figure 1). Local analgesia was administered through a paravertebral block. Chest drains were placed, and the surgical wounds were closed in three layers.

Figure 1 Thoracoscopic thymectomy in a patient with pemphigus (1). Available online:


This case is of particular interest, as pemphigus foliaceus, which is an autoimmune condition characterised by bullous skin lesions, has a well-documented association with neoplasms such as thymoma, although the exact mechanism remains unclear (2-4). VATS was particularly preferable to a conventional sternotomy for thymectomy, as the patient had significant keloid scarring on his central chest that could be exacerbated by surgical manipulation. Furthermore, VATS is associated with benefits such as postoperative pain, shorter hospital stay, and similar efficacy when compared to transsternal thymectomy (5,6), although large randomised trials with long-term followup are needed to comprehensively compare the oncological outcomes. In our opinion, electrocautery utilising a 3-mm ball-tip has several advantages compared to conventional diathermy techniques. It can contour the dissection plane, has a lower risk of injury to vascular structures, and when on high power, provides 2 to 3 mm of tissue penetration (7).




Conflicts of interest: The authors have no conflicts of interest to declare.


  1. Xie A, Yan TD. Thoracoscopic thymectomy in a patient with pemphigus. Asvide 2015;2:150. Available online:
  2. Ruocco E, Wolf R, Ruocco V, et al. Pemphigus: associations and management guidelines: facts and controversies. Clin Dermatol 2013;31:382-90. [PubMed]
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  4. Takeshita K, Amano M, Shimizu T, et al. Thymoma with pemphigus foliaceus. Intern Med 2000;39:742-7. [PubMed]
  5. Zahid I, Sharif S, Routledge T, et al. Video-assisted thoracoscopic surgery or transsternal thymectomy in the treatment of myasthenia gravis? Interact Cardiovasc Thorac Surg 2011;12:40-6. [PubMed]
  6. Jurado J, Javidfar J, Newmark A, et al. Minimally invasive thymectomy and open thymectomy: outcome analysis of 263 patients. Ann Thorac Surg 2012;94:974-81. [PubMed]
  7. Sugarbaker PH. Dissection by electrocautery with a ball tip. J Surg Oncol 1994;56:246-8. [PubMed]
Cite this article as: Xie A, Yan TD. Thoracoscopic thymectomy in a patient with pemphigus. Ann Cardiothorac Surg 2015;4(6):571-572. doi: 10.3978/j.issn.2225-319X.2015.11.03

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