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Results of frozen elephant trunk from the international E-vita Open registry

	author = {Konstantinos Tsagakis and Davide Pacini and Martin Grabenwöger and Michael A. Borger and Nora Goebel and Wolfgang Hemmer and Alvaro Laranjeira Santos and Thanos Sioris and Kazimierz Widenka and Petar Risteski and Jorge Mascaro and Igor Rudez and Andreas Zierer and Carlos A. Mestres and Arjang Ruhparwar and Roberto Di Bartolomeo and Heinz Jakob},
	title = {Results of frozen elephant trunk from the international E-vita Open registry},
	journal = {Annals of Cardiothoracic Surgery},
	volume = {9},
	number = {3},
	year = {2020},
	keywords = {},
	abstract = {Background: Over the years, frozen elephant trunk (FET) has become the treatment of choice for multisegmental thoracic aortic disease. This multicenter study presents the evolution of FET results using the E-vita Open hybrid graft with respect to institutional experience and time.
Methods: The data of International E-vita Open registry were studied according to the institutional experience of the participating centers (high- versus low-volume centers) and according to the evolution of FET treatment during time (1st period, 2005–2011 versus 2ndd period, 2012–2018). Overall, 1,165 patients were enrolled in the study with a wide variety of multisegmental thoracic aortic pathologies and aortic emergencies. Participating centers determined their own surgical protocol.
Results: The overall 30-day mortality was 12%. Short- and long-term survival were higher in high- versus low-volume centers (P=0.048 and P=0.013, respectively). In the 2nd time period, cerebral complications were reduced significantly (P=0.015). Incidence of permanent spinal cord-related symptoms was reduced to 3% in the 2nd time period, but did not reach statistical significance. Hypothermic circulatory arrest time (P},
	issn = {2225-319X},	url = {}