TY - JOUR AU - Tsagakis, Konstantinos AU - Pacini, Davide AU - Grabenwöger, Martin AU - Borger, Michael A. AU - Goebel, Nora AU - Hemmer, Wolfgang AU - Santos, Alvaro Laranjeira AU - Sioris, Thanos AU - Widenka, Kazimierz AU - Risteski, Petar AU - Mascaro, Jorge AU - Rudez, Igor AU - Zierer, Andreas AU - Mestres, Carlos A. AU - Ruhparwar, Arjang AU - Bartolomeo, Roberto Di AU - Jakob, Heinz PY - 2020 TI - Results of frozen elephant trunk from the international E-vita Open registry JF - Annals of Cardiothoracic Surgery; Vol 9, No 3 (May 29, 2020): Frozen Elephant Trunk Y2 - 2020 KW - N2 - Background: Over the years, frozen elephant trunk (FET) has become the treatment of choice for multisegmental thoracic aortic disease. This multicenter study presents the evolution of FET results using the E-vita Open hybrid graft with respect to institutional experience and time. Methods: The data of International E-vita Open registry were studied according to the institutional experience of the participating centers (high- versus low-volume centers) and according to the evolution of FET treatment during time (1st period, 2005–2011 versus 2ndd period, 2012–2018). Overall, 1,165 patients were enrolled in the study with a wide variety of multisegmental thoracic aortic pathologies and aortic emergencies. Participating centers determined their own surgical protocol. Results: The overall 30-day mortality was 12%. Short- and long-term survival were higher in high- versus low-volume centers (P=0.048 and P=0.013, respectively). In the 2nd time period, cerebral complications were reduced significantly (P=0.015). Incidence of permanent spinal cord-related symptoms was reduced to 3% in the 2nd time period, but did not reach statistical significance. Hypothermic circulatory arrest time (P UR - https://www.annalscts.com/article/view/16715