%0 Journal Article %T An updated meta-analysis of MitraClip versus surgery for mitral regurgitation %A Oh, Nicholas A. %A Kampaktsis, Polydoros N. %A Gallo, Michele %A Guariento, Alvise %A Weixler, Viktoria %A Staffa, Steven J. %A Avgerinos, Dimitrios V. %A Colli, Andrea %A Doulamis, Ilias P. %J Annals of Cardiothoracic Surgery %D 2020 %B 2020 %9 %! An updated meta-analysis of MitraClip versus surgery for mitral regurgitation %K %X Background: Although studies demonstrate its feasibility, there is ongoing debate on the short and long-term outcomes of MitraClip versus surgical repair or mitral valve replacement (MVR). The objective of this meta-analysis is to compare the safety, morbidity, mortality and long-term function following MitraClip compared to MVR. Methods: Articles were searched in Pubmed and Cochrane databases for studies comparing outcomes of MitraClip and surgery on December 1, 2019. Eligible prospective, retrospective, randomized and non-randomized studies were reviewed. Results: A total of nine studies (n=1,873, MitraClip =533, MVR =644) were eligible for review. At baseline, MitraClip patients had more comorbidities than MVR patients, including myocardial infarction (P Conclusions: Compared to surgery, MitraClip demonstrates a similar safety profile and shorter length of stay in high-risk patients, at the expense of increased residual mitral regurgitation and higher reoperation rate. Despite this, long term mortality appears comparable between the two techniques, suggesting that a patient-tailored approach will lead to optimal results. %U https://www.annalscts.com/article/view/16770 %V 10 %N 1 %P 1-14 %@ 2304-1021