TY - JOUR AU - Sorajja, Paul AU - Ukaigwe, Anene C. PY - 2020 TI - Edge-to-edge repair: past challenge, current case selection and future advances JF - Annals of Cardiothoracic Surgery; Vol 10, No 1 (January 29, 2021): Transcatheter Mitral Valve Replacement Y2 - 2020 KW - N2 - Severe mitral regurgitation (MR) is associated with heart failure and impaired survival with an annual mortality risk in excess of 5% per year for unoperated patients. Despite availability of surgical mitral valve interventions, as much as half of all patients with severe MR do not receive interventions. Transcatheter edge-to-edge repair with MitraClip has been a revolutionary therapy for MR, with over 100,000 treated patients worldwide. The usage has also expanded to different challenging anatomies as well as tricuspid regurgitation. Additionally, other transcatheter edge-to-edge repair devices are being studied. The evolution of these devices as well as what to expect in the future will be discussed here. UR - https://www.annalscts.com/article/view/16781