TY - JOUR AU - Mariani, Silvia AU - Li, Tong AU - Bounader, Karl AU - Boethig, Dietmar AU - Schöde, Alexandra AU - Hanke, Jasmin S. AU - Michaelis, Jana AU - Napp, L. Christian AU - Berliner, Dominik AU - Dogan, Guenes AU - Lorusso, Roberto AU - Haverich, Axel AU - Schmitto, Jan D. PY - 2021 TI - Sex differences in outcomes following less-invasive left ventricular assist device implantation JF - Annals of Cardiothoracic Surgery; Vol 10, No 2 (March 31, 2021): Continuous-Flow MCS in End-Stage Heart Failure I Y2 - 2021 KW - N2 - Background: Worse outcomes in women compared to men undergoing left ventricular assist device (LVAD) implantation remain an underestimated problem in heart failure (HF) patients. With device miniaturization, less-invasive LVAD implantation techniques have gained relevance, but their impact on outcomes in women is unknown. This study investigates sex-related differences in patients undergoing LVAD implantation through less-invasive procedures. Methods: This retrospective single-center cohort study included patients who underwent isolated LVAD implantation between 2011 and 2018 through less-invasive techniques. Propensity score matching (PSM) was utilized to balance preoperative heterogeneity. Primary endpoint was two-year survival, and secondary endpoints included long-term survival, surgical outcomes and postoperative adverse events. Results: Baseline analysis of 191 patients (females 18.3%) showed differences in terms of age [female (median, 52; IQR, 47–61); male (median, 58.5; IQR, 49–66); P=0.005], underlying diagnosis (P UR - https://www.annalscts.com/article/view/16807