@article{ACS17113,
author = {Douglas R. Johnston and Christopher Mehta and S. Christopher Malaisrie and Abigail S. Baldridge and Duc T. Pham and Benjamin Bryner and Melissa G. Medina and Stephen Chiu and Kevin E. Hodges and Patrick M. McCarthy},
title = {Implanted size and structural valve deterioration in the Edwards Magna bioprosthesis},
journal = {Annals of Cardiothoracic Surgery},
volume = {13},
number = {3},
year = {2024},
keywords = {},
abstract = {Background: The desire of patients to avoid anticoagulation, together with the potential of valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR), have resulted in the increasing use of bioprosthetic valves for aortic valve replacement (AVR). While patient-prosthesis mismatch (PPM) is known to be an adverse risk after AVR, few studies have addressed the effect of PPM on valve durability. This study evaluates the role of valve size and hemodynamics on long term durability after AVR with a Magna bioprosthesis.
Methods: We performed a retrospective, single-center evaluation of patients who underwent a surgical AVR procedure between June 2004 through December 2022 using the Magna bioprosthesis. Perioperative information and long-term follow-up data were sourced from the institution’s Society for Thoracic Surgeons Adult Cardiac Surgery Registry and outcomes database. Cumulative incidence of freedom from reintervention were estimated accounting for competing events. Group comparisons used Gray’s test.
Results: Among 2,100 patients, the mean patient age was 69 years (range, 22–95 years), of whom 98% had native aortic valve disease, 32.5% had concomitant coronary bypass grafting, and 19% had mitral valve surgery. Median follow-up was 5.8 (1.9–9.4) years, during which 116 reinterventions were performed, including 74 explants and 42 VIV procedures. Nine hundred and twenty-eight patients died prior to reintervention. Incidence of all cause reintervention was 1.2%, 4.5%, and 11.7% at 5, 10, and 15 years, respectively. Smaller valve size was associated with worse survival (P},
issn = {2304-1021}, url = {https://www.annalscts.com/article/view/17113}
}