TY  - JOUR
AU  - Joshi, Yashutosh
AU  - MacLean, Campbell
AU  - Emmanuel, Sam
AU  - Wang, Katherine
AU  - Soto, Claudio
AU  - Villanueva, Jeanette
AU  - Gao, Ling
AU  - Doyle, Aoife
AU  - Dutta, Sanjay
AU  - Wu, Jianxin
AU  - Vaidhya, Nikunj
AU  - Granger, Emily
AU  - Watson, Alasdair
AU  - Connellan, Mark
AU  - Iyer, Arjun
AU  - Jansz, Paul
AU  - Macdonald, Peter
PY  - 2024
TI  - Australian outcomes from heart transplantation in the machine perfusion era
JF  - Annals of Cardiothoracic Surgery; Vol 13, No 6 (November 30, 2024): Heart Transplantation In Controlled Donation After Circulatory Death I
Y2  - 2024
KW  - 
N2  - Background: In the current era of heart transplantation, machine perfusion strategies are emerging as potential additions to the armamentarium of a transplant unit. Donation after circulatory death (DCD) donor hearts assessed through normothermic machine perfusion (NMP) has helped expand the donor pool. Hypothermic machine perfusion (HMP) is emerging as an alternative strategy to traditional static cold storage (SCS) when a prolonged ischemic time is anticipated in brain dead (BD) donors, this is important in Australia where long distant procurement is vital. In this study we examine the outcomes in our unit where both forms of machine perfusion (NMP and HMP), as well as SCS is utilized for donor heart preservation, with a particular focus on severe primary graft dysfunction (sPGD) and mortality.   Methods: The year 2021 represents the year when both forms of machine perfusion were available to our unit. Heart transplants in our unit from January 2021 to February 2024 were categorized into three groups for retrospective analysis: (I) DCD-NMP group (n=44); (II) BD-HMP group (n=38), and (III) BD-SCS group (n=78).  Results: There were no significant differences in the mean donor and recipient ages between the three groups. Donor preservation time in the BD-HMP group was significantly longer than the donor ischemic time in the BD-SCS group, and organ care system (OCS) run time in the DCD-NMP group (361±89 vs. 208±47 and 249±49 min respectively, P
UR  - https://www.annalscts.com/article/view/17134