TY  - JOUR
AU  - Bombace, Sara
AU  - Fortuni, Federico
AU  - Zancanaro, Edoardo
AU  - Luca, Valeria Maria De
AU  - Schlotter, Florian
AU  - Rommel, Karl-Philipp
AU  - Mauro, Michele Di
AU  - Squeri, Angelo
AU  - Carluccio, Erberto
AU  - Condorelli, Gianluigi
AU  - Sannino, Anna
AU  - Kresoja, Karl-Patrik
AU  - Lurz, Philipp
PY  - 2026
TI  - Outcomes after tricuspid transcatheter edge-to-edge repair: a systematic review and meta-analysis
JF  - Annals of Cardiothoracic Surgery; Vol 15, No 3 (May 31, 2026): Transcatheter & Surgical Management of Tricuspid Valve Disease: Multidisciplinary Lifetime Management Considerations II
Y2  - 2026
KW  - 
N2  - Background: Severe tricuspid regurgitation (TR) is associated with high morbidity and mortality. Tricuspid transcatheter edge-to-edge repair (T-TEER) improves TR severity and symptoms, yet survival benefit remains uncertain. This meta-analysis aims to evaluate 1-year outcomes after T-TEER and explore clinical and echocardiographic correlates of prognosis.  Methods: A systematic search of PubMed/MEDLINE, Web of Science, and Scopus was conducted through June 2025. Studies enrolling ≥100 patients undergoing T-TEER and reporting 1-year outcomes were included. Primary endpoints were 1-year all-cause mortality, heart failure (HF) hospitalization, and persistence of New York Heart Association (NYHA) class III–IV. Early residual TR (≥3+), assessed at the earliest post-procedural time point within 30 days, was a secondary endpoint.   Results: Ten studies, including 4,134 patients, were analyzed. At 1-year, pooled all-cause mortality was 14.0% [95% confidence interval (CI): 9.6–18.5%], HF hospitalization 16.9% (95% CI: 8.7–25.1%), and 30.9% of patients remained in NYHA class III–IV (95% CI: 22.1–39.7%). Early residual TR ≥3+ occurred in 19.1%. In meta-regression analysis, more contemporary recruitment periods were associated with lower 1-year mortality, whereas single-center design was associated with higher early residual TR ≥3+. Exploratory aggregate-level analyses suggested potential associations between comorbidity burden and mortality, right-sided dysfunction and HF hospitalization, and left-sided disease and persistent functional limitation.   Conclusions: T-TEER effectively reduces TR and improves functional status; however, 1-year mortality and HF hospitalization remain substantial. More contemporary recruitment periods were associated with lower 1-year all-cause mortality, suggesting improved outcomes over time. Systemic comorbidity burden, right-sided disease, and concomitant left-sided disease may contribute to residual risk after T-TEER; however, these associations should be considered hypothesis-generating and require validation in individual patient-level datasets.
UR  - https://www.annalscts.com/article/view/17557