Conventional and alternative sites for left ventricular assist device inflow and outflow cannula placement
Art of Operative Techniques

Conventional and alternative sites for left ventricular assist device inflow and outflow cannula placement

Antonio Loforte1, Tomaso Bottio2, Matteo Attisani3, Sofia Martin Suarez1, Vincenzo Tarzia2, Marco Pocar3, Luca Botta1, Gino Gerosa2, Mauro Rinaldi3, Davide Pacini1

1Division of Cardiac Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2Department of Cardiac Surgery, Centro Gallucci, Padua University, Padua, Italy; 3Department of Cardiac Surgery, Città della Salute e della Scienza, Turin University, Turin, Italy

Correspondence to: Dr. Antonio Loforte, MD, PhD. Cardiac Surgeon, Department of Cardiac Surgery, S. Orsola Hospital, ALMA Mater Studiorum University of Bologna, Via Massarenti n.9, 40138 Bologna, Italy. Email:

Left ventricular assist device (LVAD) therapy is a well accepted and effective strategy to treat advanced heart failure. The miniaturized third-generation centrifugal pumps HeartWare HVAD (Medtronic, Dublin, Ireland) and HeartMate 3 (Abbott, Illinois, USA) are the two most commonly implanted systems in the contemporary era. Their design has allowed clinicians to pioneer several alternate and less invasive implantation techniques to tackle a broad spectrum of clinical scenarios. A brief review and discussion of alternative surgical techniques for both inflow and outflow cannula insertion, in the contemporary LVAD surgery era, are herein reported.

Keywords: Left ventricular assist device (LVAD); less invasive cardiac surgery; inflow cannula; outflow cannula; biventricular assist device (BiVAD)

Submitted Nov 04, 2020. Accepted for publication Mar 14, 2021.

doi: 10.21037/acs-2020-cfmcs-28


Left ventricular assist device (LVAD) therapy is a well accepted and effective strategy to treat advanced heart failure (1-3). Advances in LVAD pump technology, evolving from bulky pulsatile devices to smaller continuous-flow (CF) pumps, combined with a better understanding of patient management, have allowed progressive improvement in long-term outcomes and pump durability after implantation (1-5).

The miniaturized third-generation centrifugal pumps HeartWare HVAD (Medtronic, Dublin, Ireland; HeartWare International, Inc., Framingham, Mass, USA) and HeartMate 3 (Abbott, Illinois, USA; Thoratec, Pleasanton, CA, USA) are the two most commonly implanted systems in the contemporary era (1-7). Their design (Figure 1) has allowed clinicians to pioneer several alternate and less invasive implantation techniques to tackle a broad spectrum of clinical scenarios (6-10).

Figure 1 Profiles of current third-generation centrifugal pumps.

A brief review and discussion on alternative surgical techniques for both inflow and outflow cannula insertion, in the contemporary LVAD surgery era, are herein reported.

Inflow cannula placement

The most recent American Association for Thoracic Surgery (AATS)/International Society for Heart and Lung Transplantation (ISHLT) guidelines (6) and European Association for Cardiothoracic Surgery (EACTS) expert consensus document (7) recommend inflow cannula placement into the left ventricular (LV) apex anterior wall, about 2 cm lateral to the left anterior descending coronary artery, parallel to the interventricular septum towards the apical axis (connecting apex and mitral valve orifice) (3,6,7). Angulating the cannula more than 7° from this axis, as well as pushing the cannula too deep into the LV chamber, negatively influence intracavitary hemodynamics and LV unloading, increasing risk of pump thrombosis (3,6,7).

Therefore, careful inflow insertion site planning and proper device choice are crucial to obtain the best postoperative outcomes. However, small or restricted left ventricles are at higher risk of postoperative complications thus requiring alternative sites for cannulation and adoption of paracorporeal pulsatile pumps (11).

Direct access to the LV apex, as during sternal-sparing approaches, without heart dislocation, may facilitate placement of the inflow cannula without need of cardiopulmonary bypass (CPB) installation (6,7).

The correct position of the sewing ring is identified under trans-esophageal echocardiographic (TEE) control, through finger or needle localization (3,6,7). The sewing ring is fastened to the LV apex with, usually, twelve pledgeted prolene sutures, placed deeply into the myocardium; after a circular or X-shaped full-thickness ventriculotomy, myocardial coring is performed and the LV chamber is inspected and freed of thrombi or trabeculae crossing the inflow site if on CPB. The inflow cannula is inserted into the LV, embedded in the sewing ring and rotated clockwise or counter-clockwise, according to the planned outflow anastomotic site (3,6-8).

Prior Dor procedure or concomitant LV aneurysm reconstruction represents a challenge because of pericardial adhesions, thin wall, apical calcification, apical thrombosis and restricted LV cavity (6,7,12). If the residual capacity of the LV and the wall tissue thickness are sufficient to prevent suction, the site of previous ventriculotomy could be suitable for the inflow cannula; alternatively, the anastomosis could be performed to a synthetic patch (Figure 2), although at the expense of device stability and hemostasis (6,7,12). In the case of restricted LV and unviable walls, a left atrial inflow cannulation could be required and adoption of a paracorporeal pulsatile pump would be a solution.

Figure 2 Left ventricular assist device insertion after concomitant left ventricular aneurysm reconstruction with a synthetic patch.

The inferior LV wall may be considered as an alternative access site (6,7,13): severely dilated LV with impaired geometry, post-infarction LV apex aneurysm and narrowed-chest patients may benefit from inflow cannula placement through the LV diaphragmatic wall (Figure 3). Technically, the LV apex is lifted upwards and the sewing ring site is identified at “Frazier’s point”, which is located laterally to the posterior descending coronary artery, at the first third of the distance from the apex to the base of the heart, far away from the papillary muscles (13). The correct position and the absence of cannula obstructions may be checked with epicardial ultrasound or digital exploration during CPB. After coring, the inflow cannula is inserted along the short axis of the LV, without reaching the interventricular septum. The pump is rotated with the outflow directed towards the right side of the heart, allowing outflow anastomosis to the ascending aorta (6,7,13). However, this technique has currently been abandoned.

Figure 3 Sewing ring placement on the inferior left ventricular wall.

Outflow graft positioning

The recommended and preferred outflow site (3,6,7) is the ascending aorta on the right curvature at about 2 cm above the sinotubular junction. After partial clamping of the aorta, anastomosis should be performed in an end-to-side fashion with a 5/0 prolene running suture with 45° angle. In the case of severe aortic calcifications a 4/0 prolene suture may be of help. This allows physiological direct flow, reducing the hemodynamic burden on the root wall and on the aortic valve and, consequently, lowering the incidence of late aortic regurgitation (3,6,7).

The course of the graft should be intrapericardial (3,6,7): during less invasive sternotomy-sparing approaches, the graft is tunneled from left side to the ascending aorta (6-10) (Figure 4). This may not always be a viable option in patients with previous cardiac surgery; with strong pericardial adhesions, an alternate site for graft anastomosis may be required.

Figure 4 Intrapericardial tunneling scheme of outflow graft from the left side to the ascending aorta, during less invasive sternotomy-sparing approaches.

The outflow line should run along the inferior right ventricle (RV) surface and laterally to the right atrium in order to avoid crossing the RV outflow tract. Care must be taken to avoid kinking or twisting of the outflow graft with the help of the longitudinal ‘black’ line markers. Graft length may be easily adjusted with clockwise or counter-clockwise rotation of the centrifugal LVAD (6-10).

An alternative course of the outflow line via a less invasive approach and bridge to transplantation (BTT) strategy may be through the transverse sinus (Figure 5) (6,7,14). This technique protects the LVAD graft from potential positional changes after sternal closure and enables easier and safer re-entry during the eventual heart transplantation. Once the transverse sinus has been identified and the membrane behind the aorta has been tunneled, a forcep is inserted through the sinus, from right to the left, and the outflow graft is pulled towards the standard anastomosis site on the ascending aorta. A Gore-Tex membrane covering the outflow is positioned in order to avoid strong adhesions. Some concerns have been reported regarding covering the strain relief and outflow graft with polytetrafluoroethylene (PTFE): despite its ‘anti-adherent’ function, it could enhance thrombus formation between the graft and the PTFE itself, causing extrinsic obstruction of the outflow. Thus a longitudinal incision of the PTFE membrane, at the time of outflow graft coverage, may be a solution (6,7). However, in patients with previous cardiac surgery, this technique is not recommended because the transverse sinus is often stuck (7,14).

Figure 5 Outflow graft tunneling through the transverse sinus.

In the case of heavy calcification or pseudoaneurysms, the ascending aorta is contra-indicated as an outflow graft anastomosis site (13,14).

Alternative sites, such as the descending thoracic aorta, supra-celiac abdominal aorta, innominate artery or subclavian arteries, have been described with acceptable results (6-10,15-17).

Outflow graft anastomosis to the descending aorta

The outflow graft anastomosis to the descending aorta is an integral part of ‘lateral LVAD implantation’ (Figure 6), which represents a viable technique in the case of chest re-entry, particularly in the presence of prior coronary artery bypass grafting (CABG) and/or valve replacement surgery (6,7,15). After thoracotomy, the inferior pulmonary ligament has to be divided in order to make a pathway to the aorta. The descending aorta is exposed from the level of the pulmonary hilum to the diaphragm. CPB or Extracorporeal Life Support (ECLS) is then established, the coring process is performed, the LVAD secured and the outflow graft is measured and deaired. Off-pump surgery may be another option for LVAD implantation. The outflow is then buried in the left pulmonary fissure and anastomosed end-to-side to the aorta during lateral partial clamping.

Figure 6 Outflow graft anastomosis to the descending aorta.

The technique may have a number of advantages, including reduced surgical trauma and less risk of haemorrhage, protection of patent bypass grafts, avoiding mobilization of the apex and consequent ventricular rupture in cases with prior mechanical mitral valve implantation, as well as compatibility with off-pump operations (15). However, the clinical benefits of avoiding re-sternotomy have to be weighed against potential risk of retrograde flow from distal anastomosis sites, which may lead to aortic root thrombosis (6,7,15).

Outflow graft anastomosis to the supra-celiac abdominal aorta

If the descending aorta displays heavy, diffuse calcification or atherosclerotic plaque, the supra-celiac abdominal aorta may be used for the outflow anastomosis site (6,7,9) (Figure 7). A left subcostal incision is preferred in this case. The aorta is exposed with extra-peritoneal access and the left diaphragm is divided to expose the heart. After femoral CPB is initiated, the LVAD is implanted on the diaphragmatic LV wall; the outflow graft is then anastomosed, in the traditional fashion. ECLS or off-pump surgery may be other options for supra-celiac LVAD implantation.

Figure 7 Outflow graft anastomosis to the supra-celiac abdominal aorta.

Outflow graft anastomosis to the innominate artery

Outflow graft anastomosis to the innominate artery is optimal in BTT and is a good alternative in cases of hostile ascending or descending aorta (6-9,16). During the standard sternotomy approach, the outflow graft runs along the RV profile, between the pericardium and the right atrium. It then passes over the superior vena cava and deep to the innominate vein to be anastomosed to the innominate artery (Figure 8). During minimally invasive approaches (upper hemi-sternotomy is the preferred access), the outflow may be tunneled either intrapericardially or, in redo cases, through the left pleural cavity (6-9,16).

Figure 8 Outflow graft anastomosis to the innominate artery.

Outflow graft anastomosis to the axillary artery

Both left and right axillary arteries may be considered as outflow graft anastomosis sites (Figure 9) (6-10). Despite the advantages in the minimally invasive surgery setting, this choice presents three main technical issues requiring evaluation before LVAD implantation: the small caliber of axillary arteries, the need for intra-thoracic tunneling through an intercostal space for the outflow graft and the risk of left arm overflow or peripheral malperfusion.

Figure 9 Scheme of outflow graft anastomosis to the left axillary artery, during less invasive sternotomy-sparing approaches.

After a subclavian or a deltopectoral incision, the axillary artery is exposed: usually, the small size of the vessel makes this technique compatible with devices in which the outflow vascular graft has a diameter no more than 10 mm. The anastomosis may be performed in different ways according to axillary artery diameter: if the diameter is larger than 8 mm, end-to-side or end-to-end anastomosis (combined with side anastomosis of distal axillary) can be used (7-10). Smaller arteries with a diameter less than 8 mm may require an 8 mm diameter prosthesis bridge 2–2.5 mm in length and a graft-to-graft anastomosis (7-10). The graft is protected with a ring-reinforced Gore-Tex membrane, preventing it from kinking and compression, and is tunneled at the first or second intercostal space. In order to avoid distal overflow, axillary artery bending is recommended: after the pump is started, bending is tightened until right and left radial pressures are balanced. Right axillary artery anastomosis was first described during HeartMate II implantation in the setting of heavily calcified ascending and descending aorta: in this case, the outflow is tunneled through the right hemidiaphragm, right pleural cavity and second intercostal space (6-10). Currently, HeartWare HVAD is the device of choice for such a surgical approach due to the smaller caliber (10 mm) outflow graft (6-10).

Despite being a well-accepted strategy, in minimally invasive surgery, arm swelling, movement impairment and neurological adverse events remain potential issues to be monitored.

Biventricular assist device (BiVAD) setting

After the first reports of the newer miniaturized LVAD systems, a fully implantable CF biventricular support has been discussed and judged feasible by the scientific community (17-20). Since 2010 several mechanical circulatory support centres have been advocating a technique which allows the use of two implantable centrifugal LVADs, HeartWare HVAD or HeartMate 3 as a biventricular assist system (BiVAD) (6,7,17-20) (Figure 10).

Figure 10 Biventricular assist device (BiVAD) setting.

Patients who need biventricular long-term support either present primarily with severe chronic biventricular failure or have suffered secondary refractory RV failure after LVAD implantation, thus requiring additional long-term RV mechanical support (6,7,17).

Currently, it is recommended that the right-sided pump be inserted into the right atrium or to the diaphragmatic RV wall (7,17).

To provide a ‘physiological’ flow range of 3 to 6 liters per minute within a system speed setting of between 2,300 and 3,600 rpms, as usually set when the HVAD is used in terms of LVAD configuration, the afterload of the right system should be somehow increased. The Berlin team recommends reducing the outflow graft diameter to let the RVAD afterload reach the levels of the systemic circulation, artificially (7,17). This can be done by reducing the graft diameter to approximately 5 mm in patients with normal and to 6–7 mm in patients with elevated pulmonary vascular resistance (7,17). Graft reduction can be performed by side-clamping and narrowing the graft by placement of titanium clips. An Hegar bar is adopted for calibration. The length of outflow conduit narrowing should be about 30 mm thus influencing the right ventricular assist device (RVAD) afterload according to Hagen-Poiseuille law (17).

To reduce the length of the inflow cannula to be inserted into the right atrium, it is recommended to add, ideally, two Teflon felt tailored rings (up to 5 mm of thickness) to the original LVAD implantation ring (7,17). If this is not available, hand-made rings of Dacron or Teflon felt velour can be tailored. Additionally, the pericardium should be cut down, laterally, preserving the phrenic nerve, and the pump body should be placed into the right pleural space and suspended by the incised pericardial wall which stays between the right atrial surface and the device housing to facilitate an optimal position of the pump and avoid deep penetration of the inflow cannula into the right heart. The RVAD should be covered by a Gore-Tex membrane to avoid damage to the lung.

More than 400 CF-BiVADs have been implanted worldwide (1,2,17-20), even in the pediatric population (18) with acceptable success rates compared to paracorporeal pulsatile BiVADs and total artificial heart (TAH) support.

The surgery for two pulsatile pumps for biventricular long-term support leads to an extensive and traumatic operation both for pump housing location and penetrating cannulae positioning (e.g., Berlin Heart Excor, Berlin Heart GmbH, Berlin, Germany). Thus, the risk of bleeding and/or infection is high (7,17).

An implantable CF BiVAD system should be considered advantageous in terms of greater comfort and quality of life. The two systems (both HeartWare HVAD and HeartMate 3) run completely silently, and even if patients have to carry a couple of controllers and four batteries, they report a higher degree of freedom and mobility (7,17-20). Future developments of the current centrifugal pumps by industry focusing on the BiVAD cohort will provide significant improvements in patients’ quality of life. TAH support by utilizing two CF radial pumps has been reported but still remains anecdotal (20).


Less invasive and alternative surgical techniques for long-term contemporary LVAD placement are technically feasible and reproducible with contemporary centrifugal devices.

Novel surgical options for inflow and outflow cannula placement may increase the number of high-risk surgical patients who may benefit from CF-LVAD therapy.

Further scrutiny is needed to clarify the potential advantages and disadvantages of these novel techniques on CF-LVAD patient outcomes.


Funding: None.


Conflicts of Interest: The authors have no conflicts of interest to declare.

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Cite this article as: Loforte A, Bottio T, Attisani M, Suarez SM, Tarzia V, Pocar M, Botta L, Gerosa G, Rinaldi M, Pacini D. Conventional and alternative sites for left ventricular assist device inflow and outflow cannula placement. Ann Cardiothorac Surg 2021;10(2):281-288. doi: 10.21037/acs-2020-cfmcs-28

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