Hemodynamic outcomes after valve-in-valve transcatheter aortic valve replacement: a single-center experience
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Hemodynamic outcomes after valve-in-valve transcatheter aortic valve replacement: a single-center experience

R. Yazan Kherallah1, Srikanth Koneru2,3, Zvonimir Krajcer2,4, Ourania Preventza5,6, Kathryn G. Dougherty2,3,4, Melissa L. McCormack1, Briana T. Costello2,4, Stephanie Coulter2, Neil E. Strickman2,3,4, Juan Carlos Plana Gomez2,3, Ali Mortazavi2,4, Jose G. Díez2,3, James J. Livesay6, Joseph S. Coselli5,6, Guilherme V. Silva2,3

1Division of Internal Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA; 2Department of Cardiology, Texas Heart Institute, Houston, TX, USA; 3Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA; 4Department of Cardiology, CHI St. Luke’s Health—Baylor St. Luke’s Medical Center, Houston, TX, USA; 5Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA; 6Department of Cardiovascular Surgery, Texas Heart Institute and CHI St Luke’s Health—Baylor St Luke’s Medical Center, Houston, TX, USA

Correspondence to: R. Yazan Kherallah, MD. 2612 Crocker Street, Houston, TX 77006, USA. Email: ykher92@gmail.com.

Background: Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has emerged as a safe, effective alternative to redo aortic valve surgery in high-risk patients with degenerated surgical bioprosthetic valves. However, ViV-TAVR has been associated high postprocedural valvular gradients, compared with TAVR for native-valve aortic stenosis.

Methods: We performed a retrospective study of all patients who underwent ViV-TAVR for a degenerated aortic valve bioprosthesis between January 1, 2013 and March 31, 2019 at our center. The primary outcome was postprocedural mean aortic valve gradient. Outcomes were compared across surgical valve type (stented versus stentless), surgical valve internal diameter (≤19 versus >19 mm), and transcatheter aortic valve type (self-expanding vs. balloon-expandable).

Results: Overall, 89 patients underwent ViV-TAVR. Mean age was 69.0±12.6 years, 61% were male, and median Society of Thoracic Surgeons Predicted Risk of Mortality score was 5.4 [interquartile range, 3.2–8.5]. Bioprosthesis mode of failure was stenotic (58% of patients), regurgitant (24%), or mixed (18%). The surgical valve was stented in 75% of patients and stentless in 25%. The surgical valve’s internal diameter was ≤19 mm in 45% of cases. A balloon-expandable transcatheter valve was used in 53% of procedures. Baseline aortic valve area and mean gradients were 0.87±0.31 cm2 and 36±18 mmHg, respectively. These improved after ViV-TAVR to 1.38±0.55 cm2 and 18±11 mmHg at a median outpatient follow-up of 331 [67–394] days. Higher postprocedural mean gradients were associated with surgical valves having an internal diameter ≤19 mm (24±13 versus 16±8, P=0.002) and with stented surgical valves (22±11 versus 12±6, P<0.001).

Conclusions: ViV-TAVR is an effective option for treating degenerated surgical aortic bioprostheses, with acceptable hemodynamic outcomes. Small surgical valves and stented surgical valves are associated with higher postprocedural gradients.

Keywords: Aortic valve; transcatheter aortic valve replacement (TAVR); valve-in-valve (ViV); aortic valve stenosis; bioprosthesis

Submitted Jul 24, 2021. Accepted for publication Aug 26, 2021.

doi: 10.21037/acs-2021-tviv-131


Redo aortic valve open surgery is associated with increased morbidity and mortality, owing to factors such as patient age and comorbidities, difficulty in surgical exposure and dissection, and surgical complexity (1,2). Recently, valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) has emerged as an alternative to open surgery, with multicenter registries showing good clinical outcomes and acceptable safety profiles (3-5).

Hemodynamic outcomes are difficult to predict, given the variability in patient characteristics, but are known to be worse after ViV-TAVR than after native-valve TAVR or redo aortic valve surgery; one registry study found that up to 30% of patients had mean gradients >20 mmHg (4). Contributive factors include surgical valve size, surgical valve type, patient-prosthesis mismatch, and type of transcatheter valve (5-9). The relative contribution of each factor is not completely understood.

We conducted this study to better characterize hemodynamic outcomes after ViV-TAVR in a large single-center cohort across a variety of clinically relevant categories, including surgical valve type, size, and internal diameter. Given the evolving use of fracturing for ViV-TAVR, we included a focus on surgical valves that are not amenable to fracturing—specifically, the Trifecta (Abbott, Abbott Park, IL) and Hancock (Medtronic, Fridley, MN) aortic valves (10).


Patient population and data collection

In this retrospective study, we identified all patients in our institutional interventional database who underwent ViV-TAVR for a degenerated aortic valve bioprosthesis between January 1, 2013 and March 31, 2019. No patients were excluded.

Patients were defined as having significant surgical valve degeneration in accordance with 2009 American Society of Echocardiography guidelines (11). Stenotic valvular degeneration was defined as a mean gradient >40 mmHg, peak aortic jet velocity >4 m/s, and an effective orifice area <0.8 cm2. Where there was discordance between mean gradient and effective area, we relied on the dimensionless obstructive index (<0.25 indicates severe stenosis). Regurgitant failure was defined as meeting echocardiographic criteria for severe regurgitation (12). Those with both moderate stenosis and moderate regurgitation were labeled as having mixed modes of failure.

Patient charts were reviewed to extract clinical data, including age, sex, surgical risk score, baseline comorbidities, and New York Heart Association (NYHA) class. Risk scores included the European System for Cardiac Operative Risk Evaluation score (EuroSCORE) (13) and the Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) (14). Surgical valve characteristics included brand, year of aortic valve replacement, type of bioprosthesis (stentless versus stented), size, internal diameter, and mode of failure (stenotic, regurgitant, or mixed). Procedural variables included use of general anesthesia, transcatheter valve type and size, access site, procedure time, use of balloon dilatation, and use of valve fracturing.


For patients who were followed at our institution, the follow-up timeline is determined by the primary interventionalist. Typically, patient follow-up occurs 30 days after discharge (the discharge follow-up) and at one year (the outpatient follow-up) unless the patient opts to follow up with a primary cardiologist at an outside institution. Transthoracic echocardiography is performed at both visits.

Clinical endpoints included technical success, in-hospital adverse events, 30-day readmission, and 30-day all-cause mortality. Technical success was defined as correct anatomical positioning of the transcatheter valve in the absence of 30-day mortality. In-hospital adverse events included acute kidney injury, stroke, vascular complications, worsening congestive heart failure, new onset or worsening of atrial fibrillation, permanent pacemaker implantation, coronary obstruction, and respiratory failure. Acute kidney injury, stroke, vascular complications, worsening congestive heart failure, atrial fibrillation, and permanent pacemaker implantation were defined according to Valve Academic Research Consortium-2 (VARC-2) criteria (15). Respiratory failure was defined as: desaturation below 89%, with a new oxygen requirement of at least two liters after ViV-TAVR; hypercarbic respiratory failure with acute rise in partial pressure of carbon dioxide to >45 mmHg in a patient who is not a chronic retainer; failure to extubate within 24 hours; or need for reintubation during the index hospitalization.

Imaging endpoints of interest included mean and peak aortic valve gradients, aortic valve area, presence of paravalvular leak, and dimensionless obstructive index. These were obtained from transthoracic echocardiograms collected at baseline, after ViV-TAVR during the index hospitalization, and at the outpatient follow-up.

Procedural details

All decisions regarding patient candidacy for ViV-TAVR versus open surgery were determined during a multidisciplinary team meeting involving interventional cardiologists, cardiothoracic surgeons, advanced imagers, and diagnostic cardiologists.

Procedural planning was complex and necessitated the consideration of various factors. All patients underwent preoperative computed tomography angiography of the heart and peripheral vasculature to evaluate risk for coronary obstruction, degree of aortic valve and arch calcification, and size and caliber of the peripheral vasculature. Patients with large-enough peripheral vessels underwent a total percutaneous transfemoral approach; otherwise, a mini-thoracotomy was performed for apical delivery. Some early procedures required femoral cutdown.

The ViV-TAVR was performed in standard fashion, as described elsewhere (16,17). All procedures were performed under transesophageal echocardiographic and fluoroscopic guidance. The valve-in-valve application was used to determine transcatheter valve size on the basis of known surgical aortic valve characteristics. The choice of a self-expanding versus balloon-expandable valve was based on operator preference. Valves were positioned in standard fashion under rapid pacing, with position confirmed via fluoroscopy and transesophageal echocardiography before final deployment.

If invasive mean gradients obtained after valve deployment were elevated, dilatation was performed at the primary operator’s discretion. Valve fracturing, if employed, was carried out according to previously described methods (18-20). Whether valve fracturing was performed before or after transcatheter valve implantation was at the operator’s discretion.

Statistical analysis

Clinical, procedural, and imaging variables were reported as median with interquartile ranges or means with standard deviations, as appropriate. Outcomes were compared across variables of interest (including surgical valve type, size, and internal diameter) by using t-test and chi-square methods, as appropriate. For non-normally distributed data and small sample sizes, we used Wilcoxon rank sum and Fisher exact tests.

Alpha was set at P<0.05. All statistical analyses used R version 3.5.3 statistical software (R Foundation for Statistical Computing, Vienna, Austria).


Baseline clinical characteristics

We identified 89 patients who underwent ViV-TAVR to repair a degenerated aortic valve bioprosthesis during the study period. Baseline clinical characteristics are shown in Table 1. Mean age was 69.0±12.6 years. Most patients were men (61%). Median STS-PROM score was 5.4 [3.2–8.5]. Baseline left ventricular ejection fraction (LVEF) was 55.0%±9.7%, with 11% of patients having an LVEF <40%. Three-quarters of the sample had NYHA functional class III or IV, 35% had a history of percutaneous coronary intervention, and 20% had a pre-existing permanent pacemaker.

Table 1

Baseline clinical demographics (n=89)

Variable Data
Male sex 54 (61%)
Age, years 69.0±12.6
EuroSCORE 9.7 [5.64–13.2]
STS-PROM score 5.4 [3.2–8.5]
LVEF, % 55.0±9.7
LVEF <40% 10 (11%)
Coronary artery disease 60 (67%)
Percutaneous coronary intervention 31 (35%)
Type 2 diabetes 27 (30%)
Atrial fibrillation 24 (27%)
Peripheral vascular disease 31 (35%)
Chronic obstructive pulmonary disease 33 (37%)
Permanent pacemaker implantation 18 (20%)
NYHA class III or IV 67 (75%)

Data are expressed as n (%), mean ± standard deviation, or median [interquartile range]. EuroSCORE, European System for Cardiac Operative Risk Evaluation score; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; STS-PROM, Society of Thoracic Surgeons Predicted Risk of Mortality.

Procedural characteristics

Procedural details are provided in Tables 2,3. Most cases were performed via a total percutaneous route (81%) under general anesthesia (85%). The type of transcatheter valve was split almost evenly between self-expanding (47%) and balloon-expandable (53%). Balloon dilatation was performed in 16% of patients before valve deployment and in 29% after valve deployment. Valve fracturing was employed in five cases (6%).

Table 2

Procedural details (n=89)

Variable Data
General anesthesia 76 (85%)
Procedure time, min 142 [98–180]
Fluoroscopy time, min 30 [19–40]
Access site
   Total percutaneous 72 (81%)
   Femoral cutdown 13 (15%)
   Transapical 2 (2%)
   Subclavian 1 (1%)
   Axillary 1 (1%)
Balloon dilatation
   Before ViV-TAVR 14 (16%)
   After ViV-TAVR 26 (29%)
Valve fracture 5 (6%)

Data are expressed as n (%) or median [interquartile range]. ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.

Table 3

Surgical and transcatheter valve characteristics (n=89)

Variable n (%)
Surgical valve characteristics
   Mode of failure
    Stenosis 52 (58%)
    Regurgitation 21 (24%)
    Mixed 16 (18%)
    Stented 67 (75%)
    Stentless 22 (25%)
   Internal diameter, mm
    ≤19 39 (45%)
    >19 48 (55%)
   Size, mm
    ≤21 33 (38%)
    23–25 42 (48%)
    ≥27 12 (14%)
   Surgical valve breakdown
    Carpentier-Edwards Perimount (Edwards Lifesciences Corp, Irvine, CA) 6 (7%)
    David procedure 1 (1%)
    Epic (Abbott) 3 (3%)
    Freestyle (Medtronic) 5 (6%)
    Hancock (Medtronic) 1 (1%)
    Homograft 14 (16%)
    Magna (Edwards Lifesciences Corp.) 3 (3%)
    Mitroflow (Sorin Group USA Inc, Arvada, CO) 5 (6%)
    Mosaic (Medtronic) 21 (24%)
    Perimount (Edwards Lifesciences Corp.) 3 (3%)
    Ross procedure 1 (1%)
    Toronto (St. Jude Medical, Minneapolis, MN) 1 (1%)
    Trifecta (Abbott) 25 (28%)
Transcatheter aortic valve characteristics
    Balloon-expandable 47 (53%)
    Self-expanding 42 (47%)
   Size, mm
    20 9 (10%)
    23 45 (51%)
    26 22 (25%)
    29 10 (11%)
    34 3 (3%)

Most of the failed surgical bioprostheses were stented (75%). Of the 22 stentless bioprostheses, 14 were homografts. Valve failure was mostly stenotic (58%), with another 18% failing due to a combination of stenosis and regurgitation and 24% having purely regurgitant failure. Surgical valve sizes in this cohort were small; almost half (45%) of the bioprostheses had internal diameters ≤19 mm.

Stented bioprostheses tended to be smaller. Of 67 stented surgical valves, 32 (48%) had a valve size ≤21 mm, and 39 (58%) had an internal diameter ≤19 mm. In comparison, of 22 stentless bioprostheses, only one (5%) had a valve size ≤21 mm, and none had an internal diameter ≤19; valve size and internal diameter characteristics were not available for two of the stentless valves. Additionally, a greater proportion of the stented valves had a stenotic mode of failure [50/67 (75%), versus 7/22 (32%) for stentless].

Early clinical outcomes

Of the 89 procedures, 88 (99%) were technically successful. One patient’s transcatheter valve had to be surgically explanted during the index hospitalization due to persistently severely elevated aortic gradients. All patients survived to discharge.

In-hospital adverse events are listed in Table 4. Permanent pacemaker implantation was required in 4% of patients. Only one transient ischemic event and no coronary obstructions were noted. There were three minor vascular complications: one access site hematoma, one foreign device embolization that was successfully retrieved without clinical sequelae, and one iliac dissection that required stenting during the procedure.

Table 4

Clinical events (n=89)

Event n (%)
30-day mortality (n=74)* 0 (0%)
30-day readmission (n=74)* 9 (12%)
Permanent pacemaker 4 (4%)
Respiratory failure 7 (8%)
Acute kidney injury 3 (3%)
Transient ischemic attack 1 (1%)
Congestive heart failure exacerbation 5 (6%)
Atrial fibrillation 6 (7%)
Coronary obstruction 0 (0%)
Minor vascular complication 3 (3%)

*, after discharge, 15 of the 89 original patients were lost to follow-up or did not otherwise provide follow-up records.

After discharge, 15 patients (17%) were lost to follow-up or otherwise did not have records available after discharge. Of the 74 patients for whom discharge follow-up data were available, nine (12%) were readmitted within 30 days of discharge, and none died.

Overall hemodynamic results

Outpatient follow-up transthoracic echocardiograms were available for 65% of patients. The median time to outpatient follow-up transthoracic echocardiography was 331 [67–394] days.

The baseline aortic valve area (AVA) of 0.87±0.31 cm2 improved to 1.54±0.54 cm2 (P<0.001) after ViV-TAVR. This improvement was maintained at the outpatient follow-up (1.38±0.55 cm2; P=0.80) (Figure 1). Mean gradients also improved significantly from baseline to post-procedure (36±18 versus 19±11 mmHg, P<0.001). This improvement also was maintained through outpatient follow-up (18±11 mmHg, P=0.48) (Figure 2). Similarly, the dimensionless obstructive index was improved post-procedure and maintained this trend at outpatient follow-up (Figure 3). Before ViV-TAVR, 86% of patients had severe patient-prosthesis mismatch; this percentage decreased to 45% after ViV-TAVR (P<0.001) (Figure 4). Of the 36 patients with at least moderate regurgitation at baseline, only three had at least moderate regurgitation after ViV-TAVR (Figure 5).

Figure 1 Change in aortic valve area after ViV-TAVR. ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.
Figure 2 Change in mean aortic valve gradient after ViV-TAVR. ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.
Figure 3 Change in dimensionless obstructive index after ViV-TAVR. ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.
Figure 4 Change in patient-prosthesis mismatch after ViV-TAVR. AVAI, aortic valve area index; ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.
Figure 5 Paravalvular leak before and after ViV-TAVR in patients with at least moderate aortic regurgitation before the procedure (n=36). ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.

Hemodynamic gradients and valve sizes at baseline and after ViV-TAVR were stratified across several variables of interest, including surgical valve type (stented versus stentless), surgical valve internal diameter (≤19 versus >19 mm), transcatheter valve type (self-expanding versus balloon-expandable), and whether the surgical valve was Trifecta. Analyses were performed for the entire cohort and then repeated without the 21 patients who had purely regurgitant bioprosthesis failure (Table 5).

Table 5

Hemodynamic outcomes across several factors

Variable Count Before ViV-TAVR After ViV-TAVR
Mean gradient, mmHg P value Mean gradient, mmHg P value DOI P value* AVA, cm2 P value Severe patient-prosthesis mismatch P value
Entire patient population (n=89)
   Internal diameter
    ≤19 mm 39 42±16 0.007* 24±13 0.002* 0.39±0.11 0.04* 1.40±0.47 0.12 42% 0.78
    >19 mm 48 32±17 16±8 0.45±0.13 1.60±0.52 35%
   SAVR type
    Stented 67 39±16 0.009* 22±11 <0.001* 0.41±0.12 0.02* 1.47±0.47 0.18 40% 0.75
    Stentless 22 25±20 12±6 0.49±0.14 1.73±0.69 31%
   ViV-TAVR type
    Balloon-expandable 49 36±16 0.90 20±10 0.41 0.41±0.11 0.08 1.51±0.59 0.62 47% 0.20
    Self-expanding 40 36±20 19±12 0.45±0.14 1.58±0.49 26%
   Fracturable valves
    Trifecta or Hancock 26 38±18 0.53 20±12 0.70 0.40±0.12 0.18 1.43±0.45 0.35 38% 0.99
    Other 64 35±17 19±11 0.44±0.13 1.56±0.58 38%
Excluding 21 patients with purely regurgitant failure (n=68)
   Internal diameter
    ≤19 mm 34 46±14 0.02* 27±12 0.006* 0.38±0.10 0.30 1.38±0.46 0.22 46% >0.99
    >19 mm 34 38±15 19±7 0.41±0.11 1.57±0.58 36%
   SAVR type
    Stented 58 42±13 0.19 23±11 0.005* 0.39±0.10 0.25 1.44±0.46 0.55 42% >0.99
    Stentless 10 38±21 15±5 0.45±0.15 1.63±0.83 38%
   ViV-TAVR type
    Balloon-expandable 40 39±14 0.10 22±10 0.65 0.40±0.11 0.75 1.50±0.63 0.44 46% 0.47
    Self-expanding 28 45±15 23±12 0.39±0.11 1.39±0.35 32%
   Fracturable valves
    Trifecta & Hancock 20 44±15.1 0.40 22.7±11.7 0.80 0.38±0.09 0.27 1.42±0.43 0.70 39% >0.99
    Other 48 40.6±14.4 21.9±10.2 0.41±0.11 1.48±0.58 41%

*, indicates significant at P<0.05; , internal diameter characteristics were not available for 2 valves. AVA, aortic valve area; DOI, dimensionless obstructive index; SAVR, surgical aortic valve replacement; ViV-TAVR, valve-in-valve transcatheter aortic valve replacement.

Post-procedural transvalvular gradients >20 mmHg were seen in 49% of patients whose bioprosthesis had an internal diameter ≤19 mm and in 23% of those whose bioprosthesis had an internal diameter >19 mm. After ViV-TAVR, valves with internal diameters ≤19 mm had higher mean hemodynamic gradients, compared with larger valves (24±13 versus 16±8 mmHg, P=0.002) (Table 5). This difference remained significant when valves with purely regurgitant modes of failure were excluded (27±12 versus 19±7 mmHg, P=0.006). Stented surgical valves also had higher hemodynamic gradients than stentless surgical valves (22±11 versus 12±6 mmHg, P<0.001). This difference remained significant when valves with purely regurgitant modes of failure were excluded (23±11 versus 15±5 mmHg, P=0.005).

No statistical differences were observed between self-expanding and balloon-expandable valves in terms of AVA, mean gradients, or patient prosthesis mismatch. However, the frequency of patient-prosthesis mismatch with balloon-expandable valves was almost double that with self-expanding valves (47% versus 26%, P=0.2), although the difference was not statistically significant. A similar trend was seen for surgical valves with internal diameters ≤19 mm versus larger valves (60% versus 31%, P=0.23) (data not shown).

Trifecta or Hancock surgical valves were found in 26 patients. Mean gradients for these patients were 38±18 mmHg before ViV-TAVR and 20±12 mmHg after ViV-TAVR. A considerable percentage of patients (36%) had mean gradients >20 mmHg after ViV-TAVR. Trifecta valves were not statistically different from other surgical valves in terms of aortic pressure gradients, AVAs, and rates of patient-prosthesis mismatch.


Data supporting the safety and efficacy of ViV-TAVR is rapidly accumulating, with various multicenter registries showing the procedure to be a safe and effective alternative to repeat open surgery in eligible patients (3,5). However, hemodynamic outcomes for ViV-TAVR are inferior to those for TAVR in native aortic valves (3,9,21,22). Up to 30% of ViV-TAVR patients have post-procedural transvalvular gradients >20 mmHg, which according to the updated VARC-2 criteria constitutes procedural failure (15). In this report, we aimed to describe our single-center hemodynamic and other outcomes after ViV-TAVR across various factors of interest.

Small internal diameters

Surgical bioprostheses with small internal diameters (≤19 mm) had significantly worse transvalvular gradients after ViV-TAVR than bioprostheses with internal diameters >19 mm. Within our sample, 49% of patients whose bioprosthesis had an internal diameter ≤19 mm had post-procedural transvalvular gradients >20 mmHg (and therefore hemodynamic failure, according to VARC-215), compared with only 23% of those with larger bioprostheses. Small surgical valves being associated with worse hemodynamic outcomes is well known (3,6,23,24). The notable result from our cohort is that rates of hemodynamic failure approached 50%, significantly higher than what has been previously described.

Patients with elevated hemodynamic gradients may have worse clinical outcomes. Therefore, caution should be exercised when operating on small surgical valves, and alternative solutions should be considered. For operable candidates, surgery that includes aortic root enlargement is associated with acceptable gradients (25,26). For non-operable candidates, valve fracturing may be useful. This was employed in only five of our patients, limiting our ability to extract data about its efficacy.

Stented versus stentless surgical valves

Much less is known about ViV-TAVR for stentless valves, as they are considerably rarer than stented valves, accounting for about 10% of implanted bioprostheses (27). Typically, stentless valves are placed in patients with small aortic annuli in an effort to optimize hemodynamics and avoid patient-prosthesis mismatch. Because they lack a stent frame, stentless valves do not provide fluoroscopic landmarks and thus pose important challenges with regard to transcatheter valve landing and sizing (7,28-32). Duncan et al. (30) compared clinical outcomes between stentless versus stented valves in an international registry and found that patients with stentless valves had a higher rate of periprocedural adverse events (including device migration) than patients with stentless valves, but that both groups had similar 30-day and 1-year clinical outcomes overall.

In our study, stentless valves were associated with significantly better post-procedural gradients compared with stented valves. This was partly related to a higher rate of regurgitant degeneration among the stentless valves. The significant difference in aortic mean gradients remained even after including only stenotic modes of failure, although our sample sizes were very small. A possible explanation would be that the lack of a stent frame allows for better compliance and more complete transcatheter valve expansion. It is important to note that all stentless valves are not equivalent. Our stentless cohort included a substantial percentage of homografts (14/22). Whether outcomes among stentless subcategories differ warrants further study.

Trifecta and Hancock surgical valves

The advent of balloon fracturing has important implications for ViV-TAVR procedures, possibly allowing for better hemodynamic results in patients with small, rigid surgical aortic valves (10,33). An important limitation of valve fracturing is that it cannot be employed with all valves. Trifecta and Hancock are notable surgical bioprostheses that cannot be fractured, due to their design (10,34). Our cohort included 25 patients with Trifecta valves and one with a Hancock valve. These valves did not differ from the other valves with regards to mean gradient, aortic valve area, or patient-prosthesis mismatch.

Valve fracturing was seldom used within our cohort. Had it been used more frequently, a difference in hemodynamics might have been observed. Nevertheless, it is reassuring that postprocedural hemodynamics in patients with Trifecta valves were acceptable, with mean gradients comparable to what has been described in the literature. More than a third of these patients (36%) had mean gradients >20 mmHg after ViV-TAVR, and 33% had severe patient-prosthesis mismatch, but these findings are less likely to be related to Trifecta valves specifically than to limitations of the general cohort.

Balloon-expandable versus self-expanding transcatheter valves

Early in vitro experiments suggest that self-expanding valves may have better hemodynamic performance than balloon-expandable valves, owing to their supra-annular position (34,35). Thus, some operators prefer to implant self-expanding valves into small surgical aortic valves. In general, we found no statistical differences in hemodynamic outcomes between self-expanding and balloon-expandable valves. There was, however, a trend toward more frequent patient-prosthesis mismatch in patients with balloon-expandable valves versus self-expanding valves. That trend persisted, although not significantly, when surgical aortic valves were compared by inner diameter [≤19 mm (60%) versus >19 mm (31%)]. This trend should be investigated in larger cohorts.

Whether or not severe patient-prosthesis mismatch has a bearing on clinical outcomes remains debatable. One-year outcomes based on data from various ViV-TAVR registries do not show an impact on 1-year mortality (36). The correlation between severe prosthesis mismatch and symptoms, readmissions, valve durability, and long-term outcomes is not well studied.


Our study has several limitations. Because this was a single-center, unrandomized cohort, the study was prone to selection bias and random error. Our patient population was not powered for many of the clinical and hemodynamic endpoints evaluated. This issue was further compounded by our breaking the sample into smaller subgroups for comparison purposes, such that we could not control for relevant covariates (e.g., the interplay between surgical valve type and internal diameter). Thus, all findings should be considered exploratory and hypothesis generating. Also, our sample would be difficult to generalize, given its makeup: We had a high percentage of Trifecta valves and homografts, and a significant proportion of our patients had very small surgical aortic valves. Furthermore, long-term follow-up was lacking.


We present the hemodynamic outcomes of ViV-TAVR in a large single-center cohort, with multiple sub-analyses according to procedural characteristics. Stentless valves were associated with better pressure gradients relative to stented valves. Larger studies should be conducted to explore these results. These considerations should inform surgeons at the time of primary surgical aortic valve repair and can assist interventionalists in predicting outcomes and assessing patient candidacy for ViV-TAVR.


Jeanie F. Woodruff, BS, ELS, contributed to the editing of the manuscript.

Funding: None.


Conflicts of Interest: Dr. Preventza participates in clinical trials with and/or consults for Terumo Aortic and W.L. Gore & Associates. Dr. Coselli participates in clinical studies with and/or consults for Terumo Aortic, Medtronic, W.L. Gore & Associates, CytoSorbents, and Abbott Laboratories and receives royalties and grant support from Terumo. None of the other authors have any potential conflict of interest with regard to the work described in this manuscript. This work was not funded by a grant or any other source of external funding.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


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Cite this article as: Kherallah RY, Koneru S, Krajcer Z, Preventza O, Dougherty KG, McCormack ML, Costello BT, Coulter S, Strickman NE, Plana Gomez JC, Mortazavi A, Díez JG, Livesay JJ, Coselli JS, Silva GV. Hemodynamic outcomes after valve-in-valve transcatheter aortic valve replacement: a single-center experience. Ann Cardiothorac Surg 2021;10(5):630-640. doi: 10.21037/acs-2021-tviv-131

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