No-touch vein grafts and the destiny of venous revascularization in coronary artery bypass grafting—a 25 anniversary perspective

No-touch vein grafts and the destiny of venous revascularization in coronary artery bypass grafting—a 25th anniversary perspective

Ninos Samano1, Michael Dashwood2, Domingos Souza3

1Department of Cardiothoracic and Vascular Surgery, University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 2Surgical and Interventional Sciences, Royal Free Hospital Campus, University College London Medical School, London, UK; 3Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

Correspondence to: Dr. Ninos Samano, MD, PhD. Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, SE-70185 Örebro, Sweden. Email:

Ischemic heart disease is currently the leading cause of death globally, with coronary artery bypass grafting among the most common operations performed worldwide. More extensive use of arterial grafts has been advocated because of their high long-term patency, long-term survival benefit, and freedom from reinterventions. Despite this, the saphenous vein is the most frequently used conduit in patients undergoing coronary artery bypass surgery since its introduction over 50 years ago. Consequently, the saphenous vein remains an indispensable conduit in coronary artery bypass grafting and maintaining its long-term patency is one of the most crucial challenges in cardiovascular surgery. This situation led to the development of the no-touch saphenous vein harvesting technique, where the vein is harvested completely with its pedicle of surrounding tissue. Several studies report a superior long-term patency rate, slower progression of atherosclerosis, and better clinical outcomes whilst employing no-touch harvesting technique. The success of the technique is multifactorial, including the decreased risk for graft spasm—and the need for manual distension—preservation of the vaso vasorum and an intact endothelium, reducing neointimal hyperplasia and subsequent atherosclerosis. Furthermore, the intact perivascular tissue, including the surrounding cushion of fat, may act as a “natural external stent”, providing mechanical support preventing the graft from kinking. We are convinced that the use of arterial grafts, in combination with the no-touch saphenous vein graft, will significantly improve the results of coronary artery bypass grafting. This is important for achieving a comprehensive and evidence-based balance between the major treatment strategies of ischemic heart disease, explicitly coronary artery bypass grafting and percutaneous coronary intervention. The no-touch technique is becoming increasingly popular among surgeons, with further studies to be initiated worldwide.

Keywords: Arterial grafts; coronary artery bypass grafting (CABG); no-touch harvesting technique (NT harvesting technique); patency; saphenous vein (SV)

Submitted Feb 01, 2018. Accepted for publication May 24, 2018.

doi: 10.21037/acs.2018.05.15


Ischemic heart disease is currently the leading cause of death globally, and is expected to account for 14.2% of all deaths by 2030 (1). Coronary artery bypass grafting (CABG) is among the most common operations performed in the world (2) and is the best treatment for advanced ischemic heart disease (3-5).

In a recent perspective in the New England Journal of Medicine, Jones (6) describes the important contributions of the Argentinian cardiac surgeon, Rene Favaloro, who introduced the saphenous vein (SV) as a conduit in patients undergoing CABG. In the subsequent 50 years, this vessel has become the most commonly used conduit for revascularization. Along with the SV, the two main vessels used for CABG are the internal thoracic artery (ITA) and the radial artery (RA).

Pros and cons

Graft patency in CABG is a major determinant of clinical prognosis, measured in terms of reoperation rates and long-term survival (7,8). More extensive use of arterial grafts has been advocated because of their high long-term patency, long-term survival benefit, and freedom from reinterventions (9-11). This is compared to the high incidence of early graft occlusion, progressive intimal hyperplasia, and late graft atherosclerosis associated with the use of conventional SV grafts (SVGs) (12,13).

Even if extensive arterial revascularization is performed, SVGs still account for the majority of conduits used in CABG (14). In many centers, the SV is used for up to 80% of all grafts (15). This is due to numerous advantages of using the SV, including ease of access and manipulation, sufficient length for grafting, and short harvesting time. Clinical factors may also suggest that prolonged conduit longevity is not always the primary concern. Old age, female gender, left ventricular dysfunction, smoking, obesity, and diabetes are some of the factors that negatively impact on survival (16,17) and hence, the benefits of extensive arterial revascularization in CABG can be short-lived in these patients (18). This consideration is even more important, given that the age and comorbidities of the CABG population are increasing (19). Consequently, the SV remains an indispensable conduit in CABG and its long-term patency is one of the most crucial challenges in cardiovascular surgery.

No-touch (NT) harvesting technique

Laboratory studies have shown that damage to vessels during surgical preparation influences graft patency (20-22). Since the early 1990s, a technique for SV preparation where the vein is harvested complete with its pedicle of surrounding tissue left intact has been employed: the “NT technique” (23,24). This technique has been shown to reduce the risk of spasm and the need for distension (23) and consequently, preserves vessel wall integrity (20). This technique provides a superior patency rate (25-28), preserved left ventricular function (29), and a better clinical outcome (30) compared to conventional harvesting, in both the short and the long term.

A prospective, randomized clinical trial which compared the NT technique with two other conventional techniques demonstrated that the patency rate of SVGs harvested with its surrounding tissue is very high at 1.5, 8.5 and 16 years postoperatively (25-27,31). This patency was comparable to that of the left ITA. Such a high patency rate has not been demonstrated when using other harvesting techniques.

A number of underlying mechanisms have been suggested as contributories to the success of NT vein grafts. For example, the decreased risk of graft spasm and the associated requirement for graft distension reduces endothelial cell loss and the resulting long-term damage (20,32,33). Other aspects include the preservation of the vasa vasorum [allowing retrograde blood flow from the graft lumen to perfuse through the vein wall (Figure 1)], thereby maintaining transmural flow and reducing ischemic damage (34). In addition, preservation of an intact luminal endothelium and local nitric oxide levels (20,34) are suggested to reduce vasospasm at harvesting and to reduce neointimal hyperplasia and subsequent atherosclerosis, decreasing the incidence of long-term graft failure (35). Furthermore, the intact perivascular tissue, including the surrounding cushion of fat, may act as a “natural external stent” that provides mechanical support, thus reducing neointimal and medial thickening of the vein graft (36,37). Importantly, preservation of the pronounced cushion of perivascular fat prevents the graft from kinking—a feature which is especially important when using sequential grafts, vital in patients with small target vessels, such as in the case of diabetics (Figure 2). In addition, perivascular adipose tissue is a source of adipocyte-derived, anticontractile factors, such as nitric oxide and leptin, which may play a role in reducing spasm and maintaining graft patency (20).

Figure 1 Representative examples of “no-touch” (NT) and conventional (CT) saphenous veins as seen at harvesting. The NT vein is removed complete with its cushion of surrounding fat whereas this fat is removed in CT vein grafts that are often also distended at high pressure to overcome spasm. The right-hand panel shows an example of a segment of NT vein with its surrounding cushion of perivascular adipose tissue (PVAT) and adventitial layer intact and a patent lumen. Scale bars =2.5 mm for left panels and 10 mm for right panel.
Figure 2 A sequential no-touch vein graft anastomosed to three small target vessels.

In several post-mortem biopsies, we observed that there are significant differences in the macroscopic aspects of atherosclerotic disease between SVGs that are harvested with the NT, versus the conventional technique (27), with the latter showing more extensive atherosclerosis. This leads us to postulate that the success of percutaneous coronary intervention (PCI) in those SVGs that develop stenosis might be significantly higher in the NT SVGs. Therefore, we propose a study to evaluate the results of PCI in SVGs of approximately 300 consecutive patients during the period 2004–2017. We aim to compare the results between those veins that were treated with the NT versus the conventional technique. Our hypothesis is that the NT technique protects the SV from developing atherosclerosis and when it occurs, the process is often limited to a specific area of the vein graft, increasing the chance of a successful PCI. This slower and more limited atherosclerosis in NT SVGs was shown in angiographic and intravascular ultrasound studies of the grafts (38).

Concerns have been raised regarding the increase in leg wound complications observed in patients receiving SVGs harvested by the NT technique. Wound complications may occur at higher rates if the technique is not employed correctly [i.e., as previously described (24)]. We would certainly prefer to provide a superior conduit with increased patency, even if a higher risk of wound infection occurs. An ideal situation would be to produce a superior conduit, combined with minimal risk of harvesting complications (39). In a recent study, Mannion et al. report that NT vein grafts, which were harvested by an open technique, had a higher patency rate compared to the conventionally harvested endoscopic veins; nonetheless, the NT group had significantly higher harvest site complications (40). However, another report demonstrated that functional wound healing was similar between NT and conventional harvesting techniques 12 months after surgery (22). With these points in consideration, our future aim must be to develop an endoscopic, minimally invasive NT SVG harvesting technique.


We are disappointed at the reluctance of surgeons to adopt the NT harvesting technique, despite considerable evidence supporting its contribution in improving SVG patency in CABG. We believe the main issue for preventing the NT technique from being internationally embraced is that, like all other surgical techniques, considerable time is required for surgeons to become familiar with and eventually implement them. Even though the NT harvesting technique was first introduced in 1996 (23), the vast majority of SVGs are still being severely damaged during harvesting.

We are convinced that the use of arterial grafts in combination with the NT SVG will significantly improve the results of CABG. This is important for achieving a comprehensive and evidence-based balance between the major treatment strategies of ischemic heart disease, explicitly, CABG and PCI.

Following the excellent patency results reported for the NT SVG, interest in the NT technique has increased dramatically worldwide. A number of multicenter randomized studies are either ongoing or are to be initiated in Canada, Sweden and China. The final results of these studies will be crucial for the future acceptance of the technique.

We close with the final message; when using an SVG in CABG, we would encourage harvesting with the NT technique.




Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: Samano N, Dashwood M, Souza D. No-touch vein grafts and the destiny of venous revascularization in coronary artery bypass grafting—a 25th anniversary perspective. Ann Cardiothorac Surg 2018;7(5):681-685. doi: 10.21037/acs.2018.05.15

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